ZNF746 and FES

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZNF746	FES
Gene Name		zinc finger protein 746	FES proto-oncogene, tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Immunoglobulin Receptor Binding Phosphatidylinositol Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Death	Protein Phosphorylation Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Axon Guidance Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Generic Transcription Pathway	Signaling by SCF-KIT Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)	Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		13 interactors: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K7 PARK2 PRKRA RPS6KA6 ZAK	31 interactors: BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR FKBP4 FKBP5 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 MDFI NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 STAT3 TERF1 TRIM28 ZNF746 ZNF775
Entrez ID		155061	2242
HPRD ID		08099	01814
Ensembl ID		ENSG00000181220	ENSG00000182511
Uniprot IDs		Q6NUN9	P07332
PDB IDs			1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Protein Phosphorylation Cellular Protein Modification Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Positive Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Kinase Activity Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neuron Projection Morphogenesis Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Signaling Neuron Projection Development Axon Guidance Negative Regulation Of Phosphorylation Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Nervous System Development Cell Part Morphogenesis Response To Oxidative Stress Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Anatomical Structure Morphogenesis Negative Regulation Of MAPK Cascade Peptidyl-amino Acid Modification Neuron Development Response To Stimulus Regulation Of JNK Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Stress-activated MAPK Cascade	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide JAK-STAT Cascade Positive Regulation Of Transport Intracellular Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Cellular Localization Regulation Of Cell Migration Signal Transduction Regulation Of Protein Transport Regulation Of Cell Motility Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Stimulus Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Response To Peptide Regulation Of Cellular Component Movement Response To Stimulus Response To Hormone Positive Regulation Of Protein Transport Cellular Response To Organic Substance Signaling Regulation Of Cell Death Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Nucleocytoplasmic Transport Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Regulation Of Protein Localization Response To Organonitrogen Compound Response To Stress Cytokine-mediated Signaling Pathway Chaperone-mediated Protein Folding Insulin Receptor Signaling Pathway Protein Import Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification ERBB Signaling Pathway Locomotion
Tagcloud ?		1alpha aav accordingly coactivator compartment conditional deleterious dysregulation editing myb mybbp1a nigra nucleolar nucleolus occupied paris parkin pd peroxisome pgc ppargamma proliferator purification rdna ribosome rrna substantia suppresses transcriptionally	1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Difference) ?		1alpha aav accordingly coactivator compartment conditional deleterious dysregulation editing myb mybbp1a nigra nucleolar nucleolus occupied paris parkin pd peroxisome pgc ppargamma proliferator purification rdna ribosome rrna substantia suppresses transcriptionally	1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Intersection) ?