ZNF746 and ZAK

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZNF746	ZAK
Gene Name		zinc finger protein 746	sterile alpha motif and leucine zipper containing kinase AZK
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Death	Cell Cycle Checkpoint DNA Damage Checkpoint Activation Of MAPKK Activity Protein Phosphorylation Response To Stress Cytoskeleton Organization Cell Cycle Arrest Activation Of JUN Kinase Activity Cell Death Cell Proliferation Response To Radiation Cell Differentiation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		13 interactors: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K7 PARK2 PRKRA RPS6KA6 ZAK	27 interactors: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP2 ZNF33A ZNF567 ZNF593 ZNF746 ZNF775
Entrez ID		155061	51776
HPRD ID		08099	11791
Ensembl ID		ENSG00000181220	ENSG00000091436
Uniprot IDs		Q6NUN9	D4Q8H0 Q9NYL2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Protein Phosphorylation Cellular Protein Modification Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Positive Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Kinase Activity Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neuron Projection Morphogenesis Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Signaling Neuron Projection Development Axon Guidance Negative Regulation Of Phosphorylation Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Nervous System Development Cell Part Morphogenesis Response To Oxidative Stress Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Anatomical Structure Morphogenesis Negative Regulation Of MAPK Cascade Peptidyl-amino Acid Modification Neuron Development Response To Stimulus Regulation Of JNK Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Stress-activated MAPK Cascade	Cellular Response To Sorbitol Positive Regulation Of Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Toll-like Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Regulation Of Caveolin-mediated Endocytosis Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Cell Death Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Innate Immune Response Apoptotic Process Programmed Cell Death Positive Regulation Of MAP Kinase Activity Transcription, DNA-templated Positive Regulation Of Neuron Death Cellular Response To Carbohydrate Stimulus Positive Regulation Of Metabolic Process Intracellular Signal Transduction Cell Death
Tagcloud ?		1alpha aav accordingly coactivator compartment conditional deleterious dysregulation editing myb mybbp1a nigra nucleolar nucleolus occupied paris parkin pd peroxisome pgc ppargamma proliferator purification rdna ribosome rrna substantia suppresses transcriptionally	adipogenic arresting associative ccpg1 chek chondrogenesis chondrogenic dedifferentiated dedifferentiation deriving dhcr24 dst g0s2 genechip hmga2 kat2 map2k6 maybe mll5 motivate msc osteogenesis prerequisites rassf4 rgs2 sesn3 transdifferentiate transdifferentiation unipotent
Tagcloud (Difference) ?		1alpha aav accordingly coactivator compartment conditional deleterious dysregulation editing myb mybbp1a nigra nucleolar nucleolus occupied paris parkin pd peroxisome pgc ppargamma proliferator purification rdna ribosome rrna substantia suppresses transcriptionally	adipogenic arresting associative ccpg1 chek chondrogenesis chondrogenic dedifferentiated dedifferentiation deriving dhcr24 dst g0s2 genechip hmga2 kat2 map2k6 maybe mll5 motivate msc osteogenesis prerequisites rassf4 rgs2 sesn3 transdifferentiate transdifferentiation unipotent
Tagcloud (Intersection) ?