FA2H and GPR37

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		FA2H	GPR37
Description		fatty acid 2-hydroxylase	G protein-coupled receptor 37
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding Fatty Acid 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Sebaceous Gland Cell Differentiation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process Glucosylceramide Biosynthetic Process Galactosylceramide Biosynthetic Process Lipid Biosynthetic Process Sphingolipid Biosynthetic Process Lipid Modification Central Nervous System Myelin Maintenance Peripheral Nervous System Myelin Maintenance Regulation Of Hair Cycle Plasma Membrane Raft Organization Ceramide Biosynthetic Process Establishment Of Skin Barrier Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process
Pathways		Sphingolipid de novo biosynthesis	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS		General cognitive ability ( 25383866) Pancreatic cancer ( 25086665) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 26237428 32341527) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)
Interacting Genes		33 interacting genes: AQP6 ARMC12 ASGR2 CD79A CREB3 CREB3L1 DLG2 EBP ELOVL4 ERGIC3 ERLIN1 FAM209A FCER1G GPR152 GPR37 GPX8 LMNA MARCHF8 MSR1 PEX12 PGRMC2 RIC3 SAR1A SGPL1 SLC10A1 SLC10A6 SLC35H1 SYT2 TLCD4 TMEM14B TMEM41A TMX2 UBQLN4	51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11
Entrez ID		79152	2861
HPRD ID		16873	03992
Ensembl ID		ENSG00000103089	ENSG00000170775
Uniprot IDs		Q7L5A8	O15354
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion
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