FA2H and TMEM41A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FA2H	TMEM41A
Description		fatty acid 2-hydroxylase	transmembrane protein 41A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Membrane
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding Fatty Acid 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity	Protein Binding
	Biological Process	Sebaceous Gland Cell Differentiation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process Glucosylceramide Biosynthetic Process Galactosylceramide Biosynthetic Process Lipid Biosynthetic Process Sphingolipid Biosynthetic Process Lipid Modification Central Nervous System Myelin Maintenance Peripheral Nervous System Myelin Maintenance Regulation Of Hair Cycle Plasma Membrane Raft Organization Ceramide Biosynthetic Process Establishment Of Skin Barrier Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		General cognitive ability ( 25383866) Pancreatic cancer ( 25086665) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		33 interacting genes: AQP6 ARMC12 ASGR2 CD79A CREB3 CREB3L1 DLG2 EBP ELOVL4 ERGIC3 ERLIN1 FAM209A FCER1G GPR152 GPR37 GPX8 LMNA MARCHF8 MSR1 PEX12 PGRMC2 RIC3 SAR1A SGPL1 SLC10A1 SLC10A6 SLC35H1 SYT2 TLCD4 TMEM14B TMEM41A TMX2 UBQLN4	9 interacting genes: CYB5B FA2H FXYD6-FXYD2 KASH5 LMNA LPAR3 NOTCH2NLA PTPN1 STX1A
Entrez ID		79152	90407
HPRD ID		16873	15539
Ensembl ID		ENSG00000103089	ENSG00000163900
Uniprot IDs		Q7L5A8	Q96HV5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity
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