FA2H and SYT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FA2H	SYT2
Description		fatty acid 2-hydroxylase	synaptotagmin 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Chromaffin Granule Membrane Synapse Exocytic Vesicle
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding Fatty Acid 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity	SNARE Binding Protein Binding Calcium-dependent Phospholipid Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding Calcium Ion Sensor Activity
	Biological Process	Sebaceous Gland Cell Differentiation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process Glucosylceramide Biosynthetic Process Galactosylceramide Biosynthetic Process Lipid Biosynthetic Process Sphingolipid Biosynthetic Process Lipid Modification Central Nervous System Myelin Maintenance Peripheral Nervous System Myelin Maintenance Regulation Of Hair Cycle Plasma Membrane Raft Organization Ceramide Biosynthetic Process Establishment Of Skin Barrier Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation	Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Calcium-dependent Activation Of Synaptic Vesicle Fusion Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis
Pathways		Sphingolipid de novo biosynthesis	Toxicity of botulinum toxin type B (botB) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Botulinum toxin type B
Diseases
GWAS		General cognitive ability ( 25383866) Pancreatic cancer ( 25086665) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Celiac disease ( 23936387) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		33 interacting genes: AQP6 ARMC12 ASGR2 CD79A CREB3 CREB3L1 DLG2 EBP ELOVL4 ERGIC3 ERLIN1 FAM209A FCER1G GPR152 GPR37 GPX8 LMNA MARCHF8 MSR1 PEX12 PGRMC2 RIC3 SAR1A SGPL1 SLC10A1 SLC10A6 SLC35H1 SYT2 TLCD4 TMEM14B TMEM41A TMX2 UBQLN4	29 interacting genes: AQP10 BNIP2 CCDC167 CLDN4 CMTM3 FA2H FUNDC2 ITGAM KLHL3 LAT MALL MIP NAPB NRXN1 ORMDL3 PLPP4 PMP22 SLC30A8 SLC35A1 SLC35A4 STON2 SYNCRIP TF THSD7B TMEM107 TMEM229B TSPO2 VAMP4 WNK1
Entrez ID		79152	127833
HPRD ID		16873	02520
Ensembl ID		ENSG00000103089	ENSG00000143858
Uniprot IDs		Q7L5A8	Q8N9I0
PDB IDs			6G5G
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity	Membrane Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Homeostatic Process Endocytic Vesicle Water Channel Activity Chemical Homeostasis
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