FA2H and MSR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FA2H	MSR1
Description		fatty acid 2-hydroxylase	macrophage scavenger receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Collagen Trimer Plasma Membrane Membrane Endocytic Vesicle Membrane Low-density Lipoprotein Particle
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding Fatty Acid 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity	Amyloid-beta Binding Scavenger Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding Cargo Receptor Activity
	Biological Process	Sebaceous Gland Cell Differentiation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process Glucosylceramide Biosynthetic Process Galactosylceramide Biosynthetic Process Lipid Biosynthetic Process Sphingolipid Biosynthetic Process Lipid Modification Central Nervous System Myelin Maintenance Peripheral Nervous System Myelin Maintenance Regulation Of Hair Cycle Plasma Membrane Raft Organization Ceramide Biosynthetic Process Establishment Of Skin Barrier Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation	Endocytosis Receptor-mediated Endocytosis Phagocytosis, Engulfment Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Cholesterol Transport Plasma Lipoprotein Particle Clearance Lipoprotein Transport Establishment Of Localization In Cell Amyloid-beta Clearance
Pathways		Sphingolipid de novo biosynthesis	Scavenging by Class A Receptors Scavenging by Class A Receptors
Drugs
Diseases
GWAS		General cognitive ability ( 25383866) Pancreatic cancer ( 25086665) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Alcohol dependence ( 26365420) Blood protein levels ( 23696881) HDL cholesterol levels in HIV infection ( 33109212) Hip circumference adjusted for BMI ( 28552196) Neurological blood protein biomarker levels ( 31320639) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		33 interacting genes: AQP6 ARMC12 ASGR2 CD79A CREB3 CREB3L1 DLG2 EBP ELOVL4 ERGIC3 ERLIN1 FAM209A FCER1G GPR152 GPR37 GPX8 LMNA MARCHF8 MSR1 PEX12 PGRMC2 RIC3 SAR1A SGPL1 SLC10A1 SLC10A6 SLC35H1 SYT2 TLCD4 TMEM14B TMEM41A TMX2 UBQLN4	9 interacting genes: ADRB2 ATP6V0C FA2H HSPA1A LEPROTL1 MALL NKG7 SEC22A SNCA
Entrez ID		79152	4481
HPRD ID		16873	01092
Ensembl ID		ENSG00000103089	ENSG00000038945
Uniprot IDs		Q7L5A8	B4DDJ5 P21757
PDB IDs			7DPX
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity	Establishment Of Localization In Cell Inclusion Body Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Vesicle-mediated Transport Vacuolar Transport Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Microtubule Polymerization Membrane Organization Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Fatty Acid 2-hydroxylase Activity Enzyme Binding Regulation Of Autophagy Beta2-adrenergic Receptor Activity Denatured Protein Binding Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Sebaceous Gland Cell Differentiation Glucosylceramide Biosynthetic Process Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Mitochondrial Membrane Organization Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Defense Response Regulated Exocytosis Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Central Nervous System Myelin Maintenance Lysosome Norepinephrine Binding Lysosomal Transport Positive Regulation Of Organelle Organization Intracellular Transport Synaptic Vesicle Membrane Death Receptor Agonist Activity Cytolytic Granule Membrane Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Response To Psychosocial Stress
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