DERL1 and CFTR

Number of citations of the paper that reports this interaction (PMID 16901789)
127

Data Source:
HPRD (in vivo)

		DERL1	CFTR
Gene Name		derlin 1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Early Endosome Late Endosome Endoplasmic Reticulum Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Cytoplasm Early Endosome Plasma Membrane Microvillus Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Endoplasmic Reticulum Sec Complex Early Endosome Membrane Chloride Channel Complex Protein Complex Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Receptor Activity Protein Binding MHC Class I Protein Binding	ATP-binding And Phosphorylation-dependent Chloride Channel Activity Chloride Channel Activity Channel-conductance-controlling ATPase Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding
	Biological Process	Response To Unfolded Protein Intracellular Transport Of Viral Protein In Host Cell ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Protein Destabilization Establishment Of Protein Localization	Cholesterol Biosynthetic Process Transport Water Transport Respiratory Gaseous Exchange Bicarbonate Transport Iodide Transport Cholesterol Transport Transepithelial Chloride Transport Lung Development Cellular Response To Hormone Stimulus Response To Cytokine Vasodilation Response To Drug Response To Peptide Hormone Response To Estrogen Positive Regulation Of Vasodilation Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity
Pathways			ABC-family proteins mediated transport
Drugs			Bumetanide Glyburide Ibuprofen Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine Crofelemer Ivacaftor
Diseases
GWAS			Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		10 interactors: AMFR APP CFTR HLA-A MFI2 RHO TCF25 UBXN6 VCP VIMP	28 interactors: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STX1A UBC UBE2I
Entrez ID		79139	1080
HPRD ID		12302	03883
Ensembl ID		ENSG00000136986	ENSG00000001626
Uniprot IDs		B4E1G1 Q9BUN8	P13569
PDB IDs			1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW
Enriched GO Terms of Interacting Partners?		ER-associated Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Red, Far-red Light Phototransduction Cellular Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of Memory T Cell Activation Synaptic Growth At Neuromuscular Junction Ubiquitin-dependent Protein Catabolic Process Cholesterol Metabolic Process Modification-dependent Protein Catabolic Process Cellular Chemical Homeostasis Collateral Sprouting In Absence Of Injury Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Immune Response Sterol Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ion Homeostasis Cellular Protein Catabolic Process Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Extracellular Matrix Disassembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of Chloride Transport Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Peptidase Activity Cell Maturation Transition Metal Ion Homeostasis Homeostatic Process Protein Catabolic Process Positive Regulation Of Plasminogen Activation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Response To Organic Substance Regulation Of Protein Deubiquitination Smooth Endoplasmic Reticulum Calcium Ion Homeostasis	Chemical Homeostasis Ion Homeostasis Transport Homeostatic Process Negative Regulation Of Glucose Import Activation Of Phospholipase C Activity Regulation Of Protein Transport Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Ion Homeostasis Regulation Of Establishment Of Protein Localization Regulation Of Catalytic Activity Cellular Localization Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of PH Positive Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Ion Transport Regulation Of Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Lyase Activity Regulation Of Phospholipase Activity Regulation Of Insulin Secretion Positive Regulation Of Lipase Activity Histone H3-T6 Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Negative Regulation Of Transport Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Synaptic Vesicle Transport Regulation Of Platelet Activation Negative Regulation Of Intracellular Signal Transduction Anion Transport Cellular Cation Homeostasis Peptidyl-serine Phosphorylation Inorganic Anion Transport Cellular Homeostasis Regulation Of Hormone Secretion Regulation Of Signaling Negative Regulation Of Nucleotide Metabolic Process Regulation Of Wound Healing
Tagcloud ?		apparatus cdt cdts chimeras complementation cytolethal derl2 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr	aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies
Tagcloud (Difference) ?		apparatus cdt cdts chimeras complementation cytolethal derl2 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr	aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies
Tagcloud (Intersection) ?