CFTR and DNAJC5

Number of citations of the paper that reports this interaction (PMID 12039948)
16

Data Source:
HPRD (in vitro)

		CFTR	DNAJC5
Gene Name		cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	DnaJ (Hsp40) homolog, subfamily C, member 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane Microvillus Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Endoplasmic Reticulum Sec Complex Early Endosome Membrane Chloride Channel Complex Protein Complex Recycling Endosome Extracellular Vesicular Exosome	Mitochondrion Lysosomal Membrane Plasma Membrane Synaptic Vesicle Membrane Melanosome Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	ATP-binding And Phosphorylation-dependent Chloride Channel Activity Chloride Channel Activity Channel-conductance-controlling ATPase Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding	Glycoprotein Binding ATP-dependent Protein Binding
	Biological Process	Cholesterol Biosynthetic Process Transport Water Transport Respiratory Gaseous Exchange Bicarbonate Transport Iodide Transport Cholesterol Transport Transepithelial Chloride Transport Lung Development Cellular Response To Hormone Stimulus Response To Cytokine Vasodilation Response To Drug Response To Peptide Hormone Response To Estrogen Positive Regulation Of Vasodilation Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity	Exocytosis Synaptic Transmission Neurotransmitter Secretion Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Secretory Pathway
Pathways		ABC-family proteins mediated transport	Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Transmission across Chemical Synapses
Drugs		Bumetanide Glyburide Ibuprofen Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine Crofelemer Ivacaftor
Diseases
GWAS		Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)	Prostate cancer ( 23535732)
Protein-Protein Interactions		28 interactors: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STX1A UBC UBE2I	3 interactors: CFTR PRKACA VAMP7
Entrez ID		1080	80331
HPRD ID		03883	08539
Ensembl ID		ENSG00000001626	ENSG00000101152
Uniprot IDs		P13569	Q6AHX3 Q9H3Z4
PDB IDs		1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW
Enriched GO Terms of Interacting Partners?		Chemical Homeostasis Ion Homeostasis Transport Homeostatic Process Negative Regulation Of Glucose Import Activation Of Phospholipase C Activity Regulation Of Protein Transport Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Ion Homeostasis Regulation Of Establishment Of Protein Localization Regulation Of Catalytic Activity Cellular Localization Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of PH Positive Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Ion Transport Regulation Of Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Lyase Activity Regulation Of Phospholipase Activity Regulation Of Insulin Secretion Positive Regulation Of Lipase Activity Histone H3-T6 Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Negative Regulation Of Transport Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Synaptic Vesicle Transport Regulation Of Platelet Activation Negative Regulation Of Intracellular Signal Transduction Anion Transport Cellular Cation Homeostasis Peptidyl-serine Phosphorylation Inorganic Anion Transport Cellular Homeostasis Regulation Of Hormone Secretion Regulation Of Signaling Negative Regulation Of Nucleotide Metabolic Process Regulation Of Wound Healing	Sperm Capacitation Water Transport Fluid Transport Regulation Of Ion Transport Positive Regulation Of Transport Positive Regulation Of Inflammatory Response Spermatid Development Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Cell Maturation Regulation Of Transmembrane Transporter Activity Spermatid Differentiation Regulation Of Protein Targeting To Vacuolar Membrane Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Ion Transport Histone H3-T6 Phosphorylation Positive Regulation Of Intracellular Transport Germ Cell Development Positive Regulation Of Histamine Secretion By Mast Cell Regulation Of Histamine Secretion By Mast Cell Eosinophil Degranulation Triglyceride Transport Regulation Of Intracellular Protein Transport Regulation Of Hormone Secretion Regulation Of Inflammatory Response Regulation Of Chloride Transport Lipid Transport Lipid Localization Iodide Transport Neutrophil Degranulation Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Organic Cyclic Compound Transepithelial Chloride Transport Regulation Of Ion Transmembrane Transport Regulation Of Intracellular Transport Endomembrane System Organization Vesicle Fusion With Golgi Apparatus Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Peptide Hormone Neutrophil Activation Involved In Immune Response Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Activation Cellular Response To Organonitrogen Compound Natural Killer Cell Degranulation
Tagcloud ?		aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies	another besides cases chinese coding common controls determine enrichment exons extremely genotyped healthy implicated major missense mutations onset parkinson pd play population rare remaining sequenced show variants
Tagcloud (Difference) ?		aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies	another besides cases chinese coding common controls determine enrichment exons extremely genotyped healthy implicated major missense mutations onset parkinson pd play population rare remaining sequenced show variants
Tagcloud (Intersection) ?