DERL1 and HLA-A

Number of citations of the paper that reports this interaction (PMID 15215855)
183

Data Source:
HPRD (in vitro)

		DERL1	HLA-A
Gene Name		derlin 1	major histocompatibility complex, class I, A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Early Endosome Late Endosome Endoplasmic Reticulum Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Medial Cisterna Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protease Binding Receptor Activity Protein Binding MHC Class I Protein Binding	Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding T Cell Receptor Binding Poly(A) RNA Binding TAP Binding
	Biological Process	Response To Unfolded Protein Intracellular Transport Of Viral Protein In Host Cell ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Protein Destabilization Establishment Of Protein Localization	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Detection Of Bacterium Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Memory T Cell Activation
Pathways			Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS			Adverse response to carbamapezine ( 21149285) Beta-2 microglubulin plasma levels ( 23417110) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 22412388) Drug-induced liver injury (amoxicillin-clavulanate) ( 21570397) HIV-1 control ( 20041166) IgA nephropathy ( 22197929) IgE levels ( 22075330) Nasopharyngeal carcinoma ( 19664746 20512145) Vitiligo ( 20410501)
Protein-Protein Interactions		10 interactors: AMFR APP CFTR HLA-A MFI2 RHO TCF25 UBXN6 VCP VIMP	25 interactors: APLP2 B2M BCAP31 CALR CANX CD8A DEK DERL1 ERBB2 KIR3DL2 LILRB1 LILRB2 MAGEA1 MAGEA4 MEOX2 PDIA3 PRKAR1A PRKCA SRC STAT3 TAPBP TRA TRB UBB ZDHHC17
Entrez ID		79139	3105
HPRD ID		12302	00826
Ensembl ID		ENSG00000136986	ENSG00000206503
Uniprot IDs		B4E1G1 Q9BUN8	B1PKY1 B2R7U3 P04439 P30443 Q5SUL5
PDB IDs			1W72 2XPG 3BO8 3RL1 3RL2
Enriched GO Terms of Interacting Partners?		ER-associated Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Red, Far-red Light Phototransduction Cellular Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of Memory T Cell Activation Synaptic Growth At Neuromuscular Junction Ubiquitin-dependent Protein Catabolic Process Cholesterol Metabolic Process Modification-dependent Protein Catabolic Process Cellular Chemical Homeostasis Collateral Sprouting In Absence Of Injury Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Immune Response Sterol Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ion Homeostasis Cellular Protein Catabolic Process Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Extracellular Matrix Disassembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of Chloride Transport Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Peptidase Activity Cell Maturation Transition Metal Ion Homeostasis Homeostatic Process Protein Catabolic Process Positive Regulation Of Plasminogen Activation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Response To Organic Substance Regulation Of Protein Deubiquitination Smooth Endoplasmic Reticulum Calcium Ion Homeostasis	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Immune System Process Antigen Processing And Presentation Of Peptide Antigen Defense Response Neurotrophin TRK Receptor Signaling Pathway Signaling Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Communication Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Immune Response Regulation Of Immune System Process Signal Transduction Homeostatic Process Cellular Response To Organic Substance Response To Stress Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemical Homeostasis Regulation Of Immune Response Regulation Of Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Response To Stimulus Regulation Of Protein Kinase Activity Fc Receptor Mediated Inhibitory Signaling Pathway Cellular Response To Stimulus Regulation Of Kinase Activity Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Viral Process Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-inhibiting Signal Transduction Response To Growth Factor Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Dendritic Cell Differentiation Negative Regulation Of T Cell Proliferation Protein Transport
Tagcloud ?		apparatus cdt cdts chimeras complementation cytolethal derl2 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr
Tagcloud (Difference) ?		apparatus cdt cdts chimeras complementation cytolethal derl2 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr
Tagcloud (Intersection) ?