CFTR and SLC4A7

Number of citations of the paper that reports this interaction (PMID 12403779)
19

Data Source:
HPRD (in vitro, in vivo)

		CFTR	SLC4A7
Gene Name		cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	solute carrier family 4, sodium bicarbonate cotransporter, member 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane Microvillus Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Endoplasmic Reticulum Sec Complex Early Endosome Membrane Chloride Channel Complex Protein Complex Recycling Endosome Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Stereocilium
	Molecular Function	ATP-binding And Phosphorylation-dependent Chloride Channel Activity Chloride Channel Activity Channel-conductance-controlling ATPase Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding	Inorganic Anion Exchanger Activity Sodium:bicarbonate Symporter Activity
	Biological Process	Cholesterol Biosynthetic Process Transport Water Transport Respiratory Gaseous Exchange Bicarbonate Transport Iodide Transport Cholesterol Transport Transepithelial Chloride Transport Lung Development Cellular Response To Hormone Stimulus Response To Cytokine Vasodilation Response To Drug Response To Peptide Hormone Response To Estrogen Positive Regulation Of Vasodilation Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity	Ion Transport Bicarbonate Transport Cochlear Nucleus Development Sodium Ion Transmembrane Transport Retinal Cell Programmed Cell Death Regulation Of Intracellular PH Transmembrane Transport Auditory Receptor Cell Development Retina Vasculature Morphogenesis In Camera-type Eye Anion Transmembrane Transport
Pathways		ABC-family proteins mediated transport	Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Bicarbonate transporters
Drugs		Bumetanide Glyburide Ibuprofen Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine Crofelemer Ivacaftor
Diseases
GWAS		Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)	Blood pressure ( 21909110) Breast cancer ( 21263130 23535729 20453838) Diastolic blood pressure ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		28 interactors: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STX1A UBC UBE2I	3 interactors: CFTR SLC4A4 YWHAB
Entrez ID		1080	9497
HPRD ID		03883	04521
Ensembl ID		ENSG00000001626	ENSG00000033867
Uniprot IDs		P13569	E9PFN4 Q9Y6M7
PDB IDs		1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW
Enriched GO Terms of Interacting Partners?		Chemical Homeostasis Ion Homeostasis Transport Homeostatic Process Negative Regulation Of Glucose Import Activation Of Phospholipase C Activity Regulation Of Protein Transport Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Ion Homeostasis Regulation Of Establishment Of Protein Localization Regulation Of Catalytic Activity Cellular Localization Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of PH Positive Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Ion Transport Regulation Of Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Lyase Activity Regulation Of Phospholipase Activity Regulation Of Insulin Secretion Positive Regulation Of Lipase Activity Histone H3-T6 Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Negative Regulation Of Transport Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Synaptic Vesicle Transport Regulation Of Platelet Activation Negative Regulation Of Intracellular Signal Transduction Anion Transport Cellular Cation Homeostasis Peptidyl-serine Phosphorylation Inorganic Anion Transport Cellular Homeostasis Regulation Of Hormone Secretion Regulation Of Signaling Negative Regulation Of Nucleotide Metabolic Process Regulation Of Wound Healing	Bicarbonate Transport Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of PH Positive Regulation Of Voltage-gated Chloride Channel Activity Inorganic Anion Transport Regulation Of Chloride Transport Negative Regulation Of Protein Dephosphorylation Iodide Transport Anion Transmembrane Transport Transepithelial Chloride Transport Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Chemical Homeostasis Transepithelial Transport Intracellular PH Elevation Ion Homeostasis Cellular Response To Hormone Stimulus Sperm Capacitation Anion Transport Cellular Homeostasis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Cytoplasmic Sequestering Of Protein Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Response To Organonitrogen Compound Chemical Homeostasis Positive Regulation Of Vasodilation Vasodilation Cholesterol Biosynthetic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Membrane Hyperpolarization Response To Hormone Sterol Biosynthetic Process Water Transport Regulation Of Vasodilation Fluid Transport Cellular Response To CAMP Positive Regulation Of Ion Transmembrane Transporter Activity Respiratory Gaseous Exchange Positive Regulation Of Transporter Activity Positive Regulation Of Mitochondrion Organization Activation Of MAPKK Activity Sterol Transport Cholesterol Transport
Tagcloud ?		aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies	atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc9a1 summarize transporters unifying
Tagcloud (Difference) ?		aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies	atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc9a1 summarize transporters unifying
Tagcloud (Intersection) ?