DERL1 and SLC7A14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DERL1	SLC7A14
Description		derlin 1	solute carrier family 7 member 14
Image			No pdb structure
GO Annotations	Cellular Component	Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	Nucleoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	Protease Binding Signal Recognition Particle Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding Protein-containing Complex Binding ATPase Binding Ubiquitin-specific Protease Binding	Protein Binding Amino Acid Transmembrane Transporter Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Response To Unfolded Protein Proteasomal Protein Catabolic Process Protein Transport Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Cellular Response To Stress Cellular Response To Unfolded Protein ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Cellular Response To Misfolded Protein	Amino Acid Transmembrane Transport Amino Acid Transport Gamma-aminobutyric Acid Import Transmembrane Transport
Pathways		ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483)	Obesity (extreme) ( 30677029) Spontaneous preterm birth without premature rupture of membranes ( 31194736)
Interacting Genes		32 interacting genes: ABHD4 AMFR APP AQP6 CFTR CIAO2A FCRL4 FFAR2 GAD2 HLA-A KASH5 LMNA LNX1 MELTF REEP4 RETREG3 RHO SCN3B SELENOS SLC10A1 SLC10A6 SLC30A8 SLC7A14 SLC7A8 TCF25 TEX44 TMED8 TMEM31 TMX2 TRIM32 UBXN6 VCP	47 interacting genes: ACSL5 ADGRE2 AGTRAP AIG1 APOL3 BET1 BNIP1 BNIP2 C1GALT1 CBLIF CCDC167 CCL4L2 CD53 CMTM5 DCBLD2 DERL1 EOGT ERMP1 FAM209A FAM20B FATE1 FCER1G FKBP7 IL10RA LINC00839 LTC4S MFF MGLL MMGT1 NINJ2 NSG1 PLPP6 PRB1 SCARF1 SCD SMCO4 TECR TMEM128 TMEM31 TRARG1 TREX1 UBIAD1 VAMP2 VKORC1 YIPF4 YIPF6 ZFPL1
Entrez ID		79139	57709
HPRD ID		12302	17222
Ensembl ID		ENSG00000136986	ENSG00000013293
Uniprot IDs		E5RGY0 Q9BUN8	Q8TBB6
PDB IDs		5GLF 7CZB 7Y4W 7Y53 7Y59
Enriched GO Terms of Interacting Partners?		Derlin-1 Retrotranslocation Complex Ubiquitin-specific Protease Binding BAT3 Complex Binding ERAD Pathway Bile Acid:sodium Symporter Activity Response To Endoplasmic Reticulum Stress Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Endoplasmic Reticulum Membrane Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Protein Binding Membrane Positive Regulation Of Chemokine Production Low-density Lipoprotein Particle Organic Anion Transport Golgi-associated Vesicle Membrane Retrograde Protein Transport, ER To Cytosol Early Endosome Membrane Positive Regulation Of Proteolysis Positive Regulation Of Insulin Secretion Very-low-density Lipoprotein Particle Endoplasmic Reticulum Tubular Network Organization Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Fusion SNAP Receptor Activity Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Vesicle Fusion Vesicle Fusion With Golgi Apparatus Cobalt Ion Transport SNARE Complex Nuclear Envelope Fatty Acid Biosynthetic Process Intestinal Epithelial Cell Development Response To Oxygen-glucose Deprivation Establishment Of Protein Localization To Plasma Membrane Vitamin K Metabolic Process Endosome To Plasma Membrane Protein Transport Endomembrane System Columnar/cuboidal Epithelial Cell Development Golgi Vesicle Transport
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