CFTR and CLCN3

Number of citations of the paper that reports this interaction (PMID 12471024)
25

Data Source:
BioGRID (pull down)

		CFTR	CLCN3
Gene Name		cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	chloride channel, voltage-sensitive 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane Microvillus Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Endoplasmic Reticulum Sec Complex Early Endosome Membrane Chloride Channel Complex Protein Complex Recycling Endosome Extracellular Vesicular Exosome	Golgi Membrane Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Vesicle Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Secretory Granule Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Specific Granule Phagocytic Vesicle
	Molecular Function	ATP-binding And Phosphorylation-dependent Chloride Channel Activity Chloride Channel Activity Channel-conductance-controlling ATPase Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Antiporter Activity PDZ Domain Binding Protein Homodimerization Activity Protein Heterodimerization Activity Volume-sensitive Chloride Channel Activity
	Biological Process	Cholesterol Biosynthetic Process Transport Water Transport Respiratory Gaseous Exchange Bicarbonate Transport Iodide Transport Cholesterol Transport Transepithelial Chloride Transport Lung Development Cellular Response To Hormone Stimulus Response To Cytokine Vasodilation Response To Drug Response To Peptide Hormone Response To Estrogen Positive Regulation Of Vasodilation Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity	Transport Regulation Of PH Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Negative Regulation Of Cell Volume Endosomal Lumen Acidification Transmembrane Transport Chloride Transmembrane Transport
Pathways		ABC-family proteins mediated transport	Ion channel transport Stimuli-sensing channels
Drugs		Bumetanide Glyburide Ibuprofen Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine Crofelemer Ivacaftor
Diseases
GWAS		Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		28 interactors: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STX1A UBC UBE2I	4 interactors: CFTR GOPC PDZK1 SLC9A3R1
Entrez ID		1080	1182
HPRD ID		03883	02785
Ensembl ID		ENSG00000001626	ENSG00000109572
Uniprot IDs		P13569	B3KXK0 B9EGJ9 P51790
PDB IDs		1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW
Enriched GO Terms of Interacting Partners?		Chemical Homeostasis Ion Homeostasis Transport Homeostatic Process Negative Regulation Of Glucose Import Activation Of Phospholipase C Activity Regulation Of Protein Transport Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Ion Homeostasis Regulation Of Establishment Of Protein Localization Regulation Of Catalytic Activity Cellular Localization Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of PH Positive Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Ion Transport Regulation Of Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Lyase Activity Regulation Of Phospholipase Activity Regulation Of Insulin Secretion Positive Regulation Of Lipase Activity Histone H3-T6 Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Negative Regulation Of Transport Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Synaptic Vesicle Transport Regulation Of Platelet Activation Negative Regulation Of Intracellular Signal Transduction Anion Transport Cellular Cation Homeostasis Peptidyl-serine Phosphorylation Inorganic Anion Transport Cellular Homeostasis Regulation Of Hormone Secretion Regulation Of Signaling Negative Regulation Of Nucleotide Metabolic Process Regulation Of Wound Healing	Regulation Of Ion Transmembrane Transport Organic Anion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Anion Transport Cytoplasmic Sequestering Of CFTR Protein Renal Phosphate Ion Absorption Positive Regulation Of Voltage-gated Chloride Channel Activity Monocarboxylic Acid Transport Spermatid Development Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Spermatid Differentiation Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Positive Regulation Of Ion Transport Regulation Of Chloride Transport Germ Cell Development Inorganic Anion Transport Regulation Of Intracellular Protein Transport Cellular Protein Localization Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Iodide Transport Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Lipid Transport Carboxylic Acid Transport Organic Acid Transport Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Sodium Ion Transmembrane Transport Lipid Localization Transepithelial Chloride Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Golgi To Plasma Membrane Protein Transport Ion Transport Negative Regulation Of Transport Bile Acid Secretion Carnitine Transport Oligopeptide Transport Regulation Of Intracellular Transport Transport Protein Localization Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Ion Homeostasis Transepithelial Transport
Tagcloud ?		aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies	10mum 200mum 3mum bkca blockers cardiac channels clamp conductance currents dids diisothiocyanatostilbene disodium disulfonic fibroblasts g0 gated heterogeneously kca1 knock na patch paxilline remarkably sirnas tetrodotoxin vol voltage
Tagcloud (Difference) ?		aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies	10mum 200mum 3mum bkca blockers cardiac channels clamp conductance currents dids diisothiocyanatostilbene disodium disulfonic fibroblasts g0 gated heterogeneously kca1 knock na patch paxilline remarkably sirnas tetrodotoxin vol voltage
Tagcloud (Intersection) ?