DERL1 and RHO

Number of citations of the paper that reports this interaction (PMID 17453418)
4

Data Source:
BioGRID (pull down)

		DERL1	RHO
Gene Name		derlin 1	rhodopsin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Early Endosome Late Endosome Endoplasmic Reticulum Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Golgi-associated Vesicle Membrane Rough Endoplasmic Reticulum Membrane Photoreceptor Outer Segment Membrane Ciliary Membrane Photoreceptor Inner Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	Protease Binding Receptor Activity Protein Binding MHC Class I Protein Binding	G-protein Coupled Receptor Activity Protein Binding Photoreceptor Activity Retinal Binding Spectrin Binding Metal Ion Binding
	Biological Process	Response To Unfolded Protein Intracellular Transport Of Viral Protein In Host Cell ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Protein Destabilization Establishment Of Protein Localization	Retinoid Metabolic Process Protein Phosphorylation Organelle Organization G-protein Coupled Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Red, Far-red Light Phototransduction Rhodopsin Mediated Signaling Pathway Protein-chromophore Linkage Regulation Of Rhodopsin Mediated Signaling Pathway Retina Development In Camera-type Eye
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Class A/1 (Rhodopsin-like receptors) Opsins VxPx cargo-targeting to cilium Assembly of the primary cilium Metabolic disorders of biological oxidation enzymes GPCR ligand binding Diseases associated with visual transduction Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade GPCR downstream signaling Visual phototransduction The phototransduction cascade The canonical retinoid cycle in rods (twilight vision) G alpha (i) signalling events
Drugs			Halothane N-Acetylmethionine 3-[Aminoethylphosphoryl]-[1,2-Di-Palmitoyl]-Sn-Glycerol Phosphonothreonine Beta-D-Mannose Alpha-D-Mannose B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Lauryl Dimethylamine-N-Oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane Heptyl 1-Thiohexopyranoside Phosphonoserine
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AMFR APP CFTR HLA-A MFI2 RHO TCF25 UBXN6 VCP VIMP	10 interactors: ADRBK1 ARR3 DERL1 GNGT1 GRK1 GRK5 GRK6 PPP2CA PRKCA SAG
Entrez ID		79139	6010
HPRD ID		12302	01584
Ensembl ID		ENSG00000136986	ENSG00000163914
Uniprot IDs		B4E1G1 Q9BUN8	P08100
PDB IDs
Enriched GO Terms of Interacting Partners?		ER-associated Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Red, Far-red Light Phototransduction Cellular Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of Memory T Cell Activation Synaptic Growth At Neuromuscular Junction Ubiquitin-dependent Protein Catabolic Process Cholesterol Metabolic Process Modification-dependent Protein Catabolic Process Cellular Chemical Homeostasis Collateral Sprouting In Absence Of Injury Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Immune Response Sterol Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ion Homeostasis Cellular Protein Catabolic Process Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Extracellular Matrix Disassembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of Chloride Transport Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Peptidase Activity Cell Maturation Transition Metal Ion Homeostasis Homeostatic Process Protein Catabolic Process Positive Regulation Of Plasminogen Activation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Response To Organic Substance Regulation Of Protein Deubiquitination Smooth Endoplasmic Reticulum Calcium Ion Homeostasis	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Phototransduction, Visible Light Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Light Stimulus Cellular Response To Radiation Signal Transduction Detection Of Abiotic Stimulus Signaling Cell Communication Regulation Of Signal Transduction Negative Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Response To Light Stimulus Apoptotic Process Response To Radiation Response To Stimulus Programmed Cell Death Cell Death Death Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Detection Of Stimulus Response To Fibroblast Growth Factor Cellular Protein Modification Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Protein Autophosphorylation Protein Phosphorylation Peptidyl-threonine Phosphorylation Photoreceptor Cell Development Activation Of Phospholipase C Activity Protein Metabolic Process Positive Regulation Of Phospholipase C Activity Nuclear Envelope Organization Negative Regulation Of Apoptotic Process
Tagcloud ?		apparatus cdt cdts chimeras complementation cytolethal derl2 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 seemed steps takes tc10 vdr
Tagcloud (Difference) ?		apparatus cdt cdts chimeras complementation cytolethal derl2 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 seemed steps takes tc10 vdr
Tagcloud (Intersection) ?