CFTR and GNAS

Number of citations of the paper that reports this interaction (PubMedID 35156780)
96

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		CFTR	GNAS
Description		CF transmembrane conductance regulator	GNAS complex locus
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Golgi-associated Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Protein-containing Complex Chloride Channel Complex Recycling Endosome Recycling Endosome Membrane	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Apical Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Trans-Golgi Network Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Isomerase Activity ATP Hydrolysis Activity Chloride Channel Regulator Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein-folding Chaperone Binding 14-3-3 Protein Binding Sec61 Translocon Complex Binding ABC-type Transporter Activity	Nucleotide Binding GTPase Activity G Protein Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase Activator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Cholesterol Biosynthetic Process Monoatomic Ion Transport Chloride Transport Water Transport Vesicle Docking Involved In Exocytosis Bicarbonate Transport Cholesterol Transport Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Transepithelial Water Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Sperm Capacitation Multicellular Organismal-level Water Homeostasis Intracellular PH Elevation Establishment Of Localization In Cell Transmembrane Transport Membrane Hyperpolarization Regulation Of Biological Quality Positive Regulation Of Enamel Mineralization Cellular Response To CAMP Amelogenesis Inorganic Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity Cellular Response To Forskolin	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Renal Water Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Female Pregnancy Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Regulation Of Signal Transduction Regulation Of Skeletal Muscle Contraction Response To Prostaglandin E Negative Regulation Of Multicellular Organism Growth Intracellular Transport Developmental Growth Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Cognition Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Acidic PH Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Positive Regulation Of Cold-induced Thermogenesis
Pathways		ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells	Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens	Pseudohypoparathyroidism Progressive osseous heteroplasia (POH) Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Glaucoma ( 30054594) Gout ( 22179738) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Type 1 diabetes ( 34012112) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Colorectal cancer ( 30529582) Creatinine levels ( 29124443) Diastolic blood pressure ( 29403010 30487518 28739976 27618452 21909115) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31152163 31015462 29124443) HDL cholesterol levels ( 32203549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 21909115) Hyperuricemia ( 29124443) Mean arterial pressure ( 29403010) Platelet distribution width ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Serum uric acid levels ( 29124443) Sulfasalazine-induced agranulocytosis ( 28762467) Systolic blood pressure ( 27618452 28739976 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 30297969 32499647) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 26785701)
Interacting Genes		466 interacting genes: A4GALT AARSD1 ABCC11 ABRAXAS1 ACCS ACOT8 ACRV1 ADAMTS1 ADAT1 ADCYAP1 ADRB3 AFMID AGBL4 AGO3 AHCYL1 AK8 AKR7A3 ALDOC ALKBH7 ANKRD49 ANKS3 ANTXR2 AP5B1 APOC2 AQP4-AS1 ARFGAP3 ARHGAP8 ARHGEF9 ARMC9 ASIC4 ASPDH ATOSB BACH1 BCAS1 BDH2 BEND5 BHLHA15 BICDL2 C19orf38 C1orf162 C7 C8orf33 C9orf43 CAB39L CABCOCO1 CALHM5 CALM2 CAMKK1 CAMKV CANX CAP1 CAPZB CASP1 CASQ2 CBR4 CCDC110 CCDC146 CCDC167 CCDC197 CCDC66 CCDC9 CCNYL6 CD22 CD68 CEP55 CFHR5 CGB2 CGB3 CGB5 CGB8 CGREF1 CHCHD10 CHMP2B CHRFAM7A CHRM4 CHRNA7 CHST14 CHST5 CIMIP5 CLCN3 CLCNKB CLEC10A CLEC12A CLEC7A CLIC1 COASY COL21A1 COL23A1 COL9A1 COPG1 COX18 CRABP1 CRACR2B CREB3L1 CSHL1 CSNK1G2-AS1 CUL1 CUTC CWC22 CYB561D1 CYP4F12 DACH2 DARS2 DAZ3 DAZ4 DDRGK1 DDX19A DDX20 DEF8 DEFB119 DEGS1 DERL1 DHX30 DLX6 DNAJA1 DNAJB14 DNAJC1 DNAJC5 DOCK10 DPF3 DPP7 DPPA3 DQX1 DRG1 DSTN DUSP7 EDF1 EEIG1 EFCAB11 EGLN3 EIF4E3 EMG1 ENPP5 EPHX1 EPO ERCC6L EREG ERICH5 ERMAP ETFA EVL EZR FAAP100 FABP2 FAM153CP FAM222A FAM9C FANCB FASTKD2 FBXO11 FCGR3A FCHO1 FGD5 FGL2 FHL2 FKBP6 FKBP6P2 FKBP7 FMOD FNIP1 FNTA GABRG2 GADD45B GAREM1 GCKR GCLM GDAP2 GFOD3P GGA1 GIMAP4 GINM1 GINS3 GNAS GNAZ GNB2 GOPC GPX1 GSDME GSTO1 GSTT2 GSTT2B GTF2F1 H2BC7 HACL1 HAND2-AS1 HAUS4 HDDC3 HEYL HHIPL2 HINT2 HK1 HMMR HNMT HOMER3 HSD17B2 HSP90AA1 HSPA14 HSPD1 HTATIP2 HTR5A IGKC IGKV1-5 IGKV2-24 IGLV4-3 IKZF2 IL12RB1 IL13 IL36A INHBA INIP INTU IQUB ISOC1 ITM2C JADE1 KATNAL1 KIF12 KLHDC7B KLHL18 KLK14 KPNA5 KRT13 KRT31 KRTAP26-1 LCMT1 LGALS14 LGALS2 LGALS9 LIAS LINC03042 LLCFC1 LMBR1L LMX1B LPCAT4 LRFN4 LRRC37B LRRC57 LSP1 LUM LURAP1L MAGEB2 MAGEC3 MAN1A1 MAP3K19 MARCHF2 MC3R MCCC2 MCPH1 MED11 MEIOB MELTF METTL14 METTL2A MGAT5B MGP MIER2 MORN3 MOS MPI MREG MRPS27 MSH4 MTFR2 MTMR14 MTRES1 MYADM MYEOV MYLK2 MYOG NAA10 NCCRP1 NEU4 NFAM1 NFIL3 NHERF1 NHERF2 NHERF4 NHLH2 NHS NIT2 NOD1 NOP53 NRIP3 NUDT1 OLFM4 OPTN OR5M8 OR7E91P OSTM1 OTC OTUD6A P2RY6 PBDC1 PBX3 PBX4 PCP4L1 PDHA1 PDIA3 PDS5B PDZK1 PGAP2 PIK3R5 PISD PLEKHB2 PNMA1 PNP POGLUT3 POLE POLR1F POU5F1 PPP1R21 PPP2R1B PRAF2 PRDM1 PRDM4 PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 PROKR1 PRSS45P PSMD4 PTCD1 PTTG1 PVRIG PWP2 PYROXD1 RASL10B RBM14 RDH12 RDH13 RFFL RFWD3 RGS13 RND3 RNF139 RNF5 RPS6KB2 RRS1 SAMD3 SAMD4B SAXO4 SCAMP1 SCN2B SDHA SDR9C7 SEC22C SEMA3E SERAC1 SERPINA3 SERPINA4 SERPINB10 SERPIND1 SERPING1 SH3BP4 SHC1 SLC10A1 SLC10A6 SLC14A1 SLC25A51P4 SLC26A11 SLC33A1 SLC35B4 SLC38A7 SLC44A5 SLC4A7 SLC4A8 SLC66A1LP SLC7A10 SLC9A6 SLC9B1 SMARCD1 SMIM21 SMYD1 SMYD3 SNAP23 SNRPN SORBS3 SOX15 SPATA6L SPEF1 SPSB3 SRP68 ST6GALNAC1 STAP2 STAU1 STIMATE STK26 STRADA STUB1 STX1A SYNE4 SYT12 TAFA3 TAFAZZIN TASL TBP TCTN3 TFEB TFF2 TFG TFR2 TGFB1 TGS1 THAP11 TIMD4 TK1 TLCD4 TLR3 TMEM237 TMEM277P TMEM40 TMPRSS6 TNFSF10 TONSL TOR1B TRAFD1 TRIM16 TRIM16L TRIM27 TRIM32 TRIM5 TRMT1 TSC22D1 TTR TXNRD2 UBE2I ULK3 UNC119 UNC45B UNC93B1 USP10 USP26 USP28 VAMP4 VAPA VAPB VASN VAV1 VDAC2 VEGFA VEPH1 VPS28 VPS4A VPS4B VTI1B WDR5B WWP2 XAGE3 XKR8 YTHDF1 ZBED2 ZC2HC1B ZDHHC15 ZFP57 ZFYVE26 ZGRF1 ZNF112 ZNF213 ZNF22 ZNF462 ZNF69 ZNF770 ZUP1	41 interacting genes: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CFTR CHEK2 CHRM3 CRHR1 CYSLTR2 DRD5 EGFR FZD7 GCGR GLP1R GNGT1 HTR6 LHB LHCGR MSANTD3 MTNR1B NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B RXFP3 SNX13 TBXA2R TSHR TTC1 VIPR1
Entrez ID		1080	2778
HPRD ID		03883	00761
Ensembl ID		ENSG00000001626	ENSG00000087460
Uniprot IDs		P13569	A0A0A0MR13 A0A0S2Z3H8 A0A0S2Z3S5 A0A590UJF0 A0A590UJQ9 A0A590UK28 A0A7I2V5R6 B0AZR9 O95467 P63092 P84996 Q14455 Q5FWY2 Q5JWD1 Q5JWE9 Q5JWF2
PDB IDs		1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW 4WZ6 5D2D 5D3E 5D3F 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFF 5TFG 5TFI 5TFJ 5TGK 5UAK 6GJQ 6GJS 6GJU 6GK4 6GKD 6HEP 6MSM 6O1V 6O2P 6UK1 6WBS 6ZE1 7QI1 7SV7 7SVD 7SVR 8EIG 8EIO 8EIQ 8EJ1 8FZQ 8GLS 8UBR 8V7Z 8V81 9DW4 9DW5 9DW7 9DW8 9DW9	5G53 5UZ7 5VAI 6AU6 6B3J 6E3Y 6E67 6EG8 6GDG 6LI3 6LMK 6LPB 6M1H 6M1I 6NI3 6NIY 6ORV 6P9X 6P9Y 6PB0 6PB1 6UUN 6UUS 6UVA 6VCB 6VN7 6WHC 6WI9 6WPW 6WZG 6X18 6X19 6X1A 6XOX 7AUE 7BB6 7BB7 7BPH 7BW0 7BZ2 7C2E 7CFM 7CFN 7CKW 7CKX 7CKY 7CKZ 7CRH 7CX2 7CX3 7CX4 7CZ5 7D3S 7D7M 7DH5 7DHI 7DHR 7DUQ 7DUR 7DW9 7E14 7E5E 7EPT 7EVM 7EZK 7F0T 7F16 7F1O 7F1Z 7F23 7F24 7F4D 7F4F 7F4H 7F4I 7F53 7F54 7F55 7F58 7JOZ 7JV5 7JVP 7JVQ 7KH0 7KI0 7KI1 7LCI 7LJC 7LJD 7LLL 7LLY 7MBX 7P02 7PIU 7PIV 7RA3 7RBT 7RG9 7RGP 7RMH 7RTB 7S1M 7S3I 7T9I 7T9N 7TMW 7TYF 7TYH 7TYI 7TYL 7TYN 7TYO 7TYW 7TYX 7TYY 7TZF 7UTZ 7V35 7V9L 7V9M 7VAB 7VBH 7VBI 7VUH 7VUI 7VUJ 7VVJ 7VVK 7VVL 7VVM 7VVN 7VVO 7WCM 7WCN 7WQ4 7WU2 7WU3 7WUI 7WUJ 7WUQ 7X2C 7X2D 7X2F 7X8R 7X8S 7XJH 7XJI 7XKD 7XKF 7XOU 7XOV 7XP4 7XP5 7XP6 7XT8 7XT9 7XTB 7XTC 7XTQ 7XW6 7XY6 7XY7 7XZ5 7XZ6 7Y35 7Y36 7Y3G 7YDP 7YP7 7YS6 8E3X 8E3Y 8E3Z 8EL7 8F0J 8F0K 8F2A 8F2B 8F76 8FLQ 8FLR 8FLS 8FLT 8FLU 8FU6 8GD9 8GDA 8GDB 8GDZ 8GE1 8GE2 8GE3 8GE4 8GE5 8GE6 8GE7 8GE8 8GE9 8GEA 8GEB 8GEC 8GED 8GEE 8GEF 8GEG 8GEH 8GEI 8GEJ 8GFV 8GFW 8GFX 8GFY 8GFZ 8GG0 8GG1 8GG2 8GG3 8GG4 8GG5 8GG6 8GG7 8GG8 8GG9 8GGA 8GGB 8GGC 8GGE 8GGF 8GW8 8H4I 8HDO 8HDP 8HIX 8HJ0 8HJ1 8HJ2 8HMP 8HMV 8HTI 8I2G 8INR 8IOC 8IOD 8IQ4 8IQ6 8IRV 8IW4 8IW7 8IW9 8IZB 8J9N 8JHB 8JHI 8JIP 8JIQ 8JIR 8JIS 8JIT 8JIU 8JLJ 8JLK 8JLO 8JLQ 8JLR 8JLZ 8JPP 8JR9 8JSO 8K8J 8KGK 8KH4 8KH5 8PM2 8POK 8QJ2 8SMV 8TB0 8TYW 8U26 8U8F 8UNL 8UNM 8UNN 8UNO 8UNP 8UNQ 8UNR 8UNS 8UNT 8UNU 8UNV 8UNW 8UNX 8UNY 8UNZ 8UO0 8UO1 8UO2 8UO3 8UO4 8UXV 8UXY 8UY0 8UYQ 8VHF 8W88 8W8Q 8W8R 8WC3 8WC4 8WC5 8WC6 8WC7 8WC8 8WG7 8WG8 8WJX 8WW2 8X2K 8X79 8X7A 8XQL 8XQR 8XVE 8XVH 8XVI 8YUT 8YW3 8YW4 8YW5 8YY8 8ZD1 8ZFZ 8ZPS 8ZPT 8ZR5 8ZRK 8ZSJ 8ZSP 8ZSS 8ZSV 9AUC 9BHL 9BHM 9BKK 9EW2 9GYO 9IVG 9J1P 9J31 9JKQ 9JR2 9JR3
Enriched GO Terms of Interacting Partners?			G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Oxygen-containing Compound Membrane System Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Pressure G-protein Alpha-subunit Binding G Protein-coupled Peptide Receptor Activity Cellular Response To Forskolin Regulation Of System Process Response To Forskolin Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Biological Quality Positive Regulation Of Lyase Activity Regulation Of Blood Circulation Regulation Of Muscle Contraction Positive Regulation Of Cyclase Activity Vascular Process In Circulatory System Regulation Of Signaling Regulation Of Cell Communication Circulatory System Process Positive Regulation Of Blood Pressure Guanyl-nucleotide Exchange Factor Activity Cellular Response To Lipid Cellular Response To Hormone Stimulus Positive Regulation Of Cytosolic Calcium Ion Concentration CAMP Biosynthetic Process Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Muscle System Process Adenylate Cyclase Binding Response To Alcohol Activation Of Adenylate Cyclase Activity Regulation Of Hormone Levels Cellular Response To Peptide Hormone Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Cell-cell Signaling Phosphorus-oxygen Lyase Activity Response To Ketone
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