CFTR and DNAJA1

Number of citations of the paper that reports this interaction (PMID 10075921)
84

Data Source:
HPRD (in vivo)

		CFTR	DNAJA1
Gene Name		cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	DnaJ (Hsp40) homolog, subfamily A, member 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane Microvillus Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Endoplasmic Reticulum Sec Complex Early Endosome Membrane Chloride Channel Complex Protein Complex Recycling Endosome Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Nucleus Mitochondrion Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	ATP-binding And Phosphorylation-dependent Chloride Channel Activity Chloride Channel Activity Channel-conductance-controlling ATPase Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding	G-protein Coupled Receptor Binding Protein Binding ATP Binding Hsp70 Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Cholesterol Biosynthetic Process Transport Water Transport Respiratory Gaseous Exchange Bicarbonate Transport Iodide Transport Cholesterol Transport Transepithelial Chloride Transport Lung Development Cellular Response To Hormone Stimulus Response To Cytokine Vasodilation Response To Drug Response To Peptide Hormone Response To Estrogen Positive Regulation Of Vasodilation Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Protein Refolding DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport
Pathways		ABC-family proteins mediated transport
Drugs		Bumetanide Glyburide Ibuprofen Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine Crofelemer Ivacaftor
Diseases
GWAS		Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		28 interactors: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STX1A UBC UBE2I	20 interactors: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LSM2 NELFCD NUDT3 PAXIP1 PTTG1 SUMO4 TM4SF1 TXN
Entrez ID		1080	3301
HPRD ID		03883	04159
Ensembl ID		ENSG00000001626	ENSG00000086061
Uniprot IDs		P13569	P31689
PDB IDs		1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW	2LO1 2M6Y
Enriched GO Terms of Interacting Partners?		Chemical Homeostasis Ion Homeostasis Transport Homeostatic Process Negative Regulation Of Glucose Import Activation Of Phospholipase C Activity Regulation Of Protein Transport Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Ion Homeostasis Regulation Of Establishment Of Protein Localization Regulation Of Catalytic Activity Cellular Localization Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of PH Positive Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Ion Transport Regulation Of Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Lyase Activity Regulation Of Phospholipase Activity Regulation Of Insulin Secretion Positive Regulation Of Lipase Activity Histone H3-T6 Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Negative Regulation Of Transport Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Synaptic Vesicle Transport Regulation Of Platelet Activation Negative Regulation Of Intracellular Signal Transduction Anion Transport Cellular Cation Homeostasis Peptidyl-serine Phosphorylation Inorganic Anion Transport Cellular Homeostasis Regulation Of Hormone Secretion Regulation Of Signaling Negative Regulation Of Nucleotide Metabolic Process Regulation Of Wound Healing	Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Negative Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination Nucleobase-containing Compound Metabolic Process Protein Polyubiquitination G2 DNA Damage Checkpoint Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Acetylation Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Histone Methylation Cell Cycle Checkpoint Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Voltage-gated Chloride Channel Activity Negative Regulation Of Fibril Organization Positive Regulation Of Histone H4-K16 Acetylation Diphosphoinositol Polyphosphate Catabolic Process Negative Regulation Of Potassium Ion Export Diadenosine Polyphosphate Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process DNA Repair Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Heart Rate By Hormone Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies	chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Difference) ?		aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies	chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Intersection) ?