DERL1 and MFI2

Number of citations of the paper that reports this interaction (PMID 16449195)
23

Data Source:
HPRD (in vivo)

		DERL1	MFI2
Gene Name		derlin 1	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Early Endosome Late Endosome Endoplasmic Reticulum Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Integral Component Of Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Receptor Activity Protein Binding MHC Class I Protein Binding	Iron Ion Binding Protein Binding Ferric Iron Binding
	Biological Process	Response To Unfolded Protein Intracellular Transport Of Viral Protein In Host Cell ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Protein Destabilization Establishment Of Protein Localization	Regulation Of Cell Growth Cellular Iron Ion Homeostasis Positive Regulation Of Plasminogen Activation Regulation Of Cell Proliferation Positive Regulation Of Extracellular Matrix Disassembly Iron Ion Import Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AMFR APP CFTR HLA-A MFI2 RHO TCF25 UBXN6 VCP VIMP	5 interactors: DERL1 DERL2 DERL3 HPGDS NOTCH2NL
Entrez ID		79139	4241
HPRD ID		12302	01122
Ensembl ID		ENSG00000136986	ENSG00000163975
Uniprot IDs		B4E1G1 Q9BUN8	P08582 Q53XS6
PDB IDs
Enriched GO Terms of Interacting Partners?		ER-associated Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Red, Far-red Light Phototransduction Cellular Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of Memory T Cell Activation Synaptic Growth At Neuromuscular Junction Ubiquitin-dependent Protein Catabolic Process Cholesterol Metabolic Process Modification-dependent Protein Catabolic Process Cellular Chemical Homeostasis Collateral Sprouting In Absence Of Injury Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Immune Response Sterol Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ion Homeostasis Cellular Protein Catabolic Process Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Extracellular Matrix Disassembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of Chloride Transport Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Peptidase Activity Cell Maturation Transition Metal Ion Homeostasis Homeostatic Process Protein Catabolic Process Positive Regulation Of Plasminogen Activation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Response To Organic Substance Regulation Of Protein Deubiquitination Smooth Endoplasmic Reticulum Calcium Ion Homeostasis	ER-associated Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Signal Transduction Signaling Cell Communication Intracellular Transport Of Viral Protein In Host Cell Cellular Response To Stimulus Cellular Response To Stress Proteolysis Cyclooxygenase Pathway Catabolic Process Cellular Response To Organic Substance Prostaglandin Biosynthetic Process Suckling Behavior Glutathione Derivative Biosynthetic Process Response To Stimulus Protein Destabilization Intracellular Transport Of Virus Behavior Prostaglandin Metabolic Process Icosanoid Biosynthetic Process Response To Organic Substance Unsaturated Fatty Acid Biosynthetic Process Intracellular Protein Transport Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Feeding Behavior Protein N-linked Glycosylation Via Asparagine Interaction With Host Unsaturated Fatty Acid Metabolic Process Response To Stress
Tagcloud ?		apparatus cdt cdts chimeras complementation cytolethal derl2 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr
Tagcloud (Difference) ?		apparatus cdt cdts chimeras complementation cytolethal derl2 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr
Tagcloud (Intersection) ?