PRKG2

Gene Name		protein kinase, cGMP-dependent, type II
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Protein Homodimerization Activity
	Biological Process	Protein Phosphorylation Signal Transduction Blood Coagulation Circadian Regulation Of Gene Expression Peptidyl-serine Autophosphorylation Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity Protein Targeting To Plasma Membrane
Pathways		Metabolism of nitric oxide Platelet homeostasis Ca2+ pathway eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nitric oxide stimulates guanylate cyclase cGMP effects Signaling by Wnt beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Height ( 19343178 23563607 18391951) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627)
Protein-protein Interactions		6 interactors: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS
Entrez ID		5593
HPRD ID		09034
Ensembl ID		ENSG00000138669
Uniprot IDs		Q13237
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Aorta Smooth Muscle Tissue Morphogenesis Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Tetrahydrobiopterin Biosynthetic Process Glucocorticoid Receptor Signaling Pathway Tonic Smooth Muscle Contraction Bleb Assembly Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Lysosome
Tagcloud ?		adamts17 arrays besides bioinformatics bmp3 causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic rodents segregating segregation short shox stature trait tulp4