PRKG2 and PTS

Number of citations of the paper that reports this interaction (PMID 10531334)
7

Data Source:
HPRD (in vitro, in vivo)

		PRKG2	PTS
Gene Name		protein kinase, cGMP-dependent, type II	6-pyruvoyltetrahydropterin synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Protein Homodimerization Activity	6-pyruvoyltetrahydropterin Synthase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Protein Phosphorylation Signal Transduction Blood Coagulation Circadian Regulation Of Gene Expression Peptidyl-serine Autophosphorylation Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity Protein Targeting To Plasma Membrane	Cellular Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity
Pathways		Metabolism of nitric oxide Platelet homeostasis Ca2+ pathway eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nitric oxide stimulates guanylate cyclase cGMP effects Signaling by Wnt beta-catenin independent WNT signaling	Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs
Diseases
GWAS		Height ( 19343178 23563607 18391951) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		6 interactors: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS	12 interactors: ATM ATR COIL FNDC5 FXR2 LNX1 PBRM1 PRKDC PRKG2 SDCBP THAP10 WDYHV1
Entrez ID		5593	5805
HPRD ID		09034	11840
Ensembl ID		ENSG00000138669	ENSG00000150787
Uniprot IDs		Q13237	Q03393
PDB IDs			3I2B
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Aorta Smooth Muscle Tissue Morphogenesis Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Tetrahydrobiopterin Biosynthetic Process Glucocorticoid Receptor Signaling Pathway Tonic Smooth Muscle Contraction Bleb Assembly Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Lysosome	Peptidyl-serine Phosphorylation Response To Gamma Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Replicative Senescence Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Response To Ionizing Radiation DNA Damage Checkpoint Double-strand Break Repair Cellular Response To Gamma Radiation V(D)J Recombination Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat Protein Autophosphorylation Cell Cycle Checkpoint DNA Recombination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Protein Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Heat Negative Regulation Of Protein Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Telomere Maintenance Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Peptidyl-amino Acid Modification Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Somitogenesis Cell Cycle Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Somite Development Mitotic DNA Damage Checkpoint Cellular Protein Modification Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle B Cell Differentiation Response To Heat Segmentation Heart Development Regulation Of Response To DNA Damage Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition
Tagcloud ?		adamts17 arrays besides bioinformatics bmp3 causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic rodents segregating segregation short shox stature trait tulp4	achieve aida apl atra became chemotherapy consolidation converting courses cytogenetic fab gimema hematologic interpretation lap0493 m3 majority molecularly morphologic mths myelogenous persistence promyelocytic q12 q22 remission successive transcript validity
Tagcloud (Difference) ?		adamts17 arrays besides bioinformatics bmp3 causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic rodents segregating segregation short shox stature trait tulp4	achieve aida apl atra became chemotherapy consolidation converting courses cytogenetic fab gimema hematologic interpretation lap0493 m3 majority molecularly morphologic mths myelogenous persistence promyelocytic q12 q22 remission successive transcript validity
Tagcloud (Intersection) ?