PRKG2 and LASP1

Number of citations of the paper that reports this interaction (PMID 12571245)
20

Data Source:
HPRD (in vitro, in vivo)

		PRKG2	LASP1
Gene Name		protein kinase, cGMP-dependent, type II	LIM and SH3 protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane	Focal Adhesion Cortical Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Protein Homodimerization Activity	SH3/SH2 Adaptor Activity Protein Binding Zinc Ion Binding Ion Transmembrane Transporter Activity Actin Filament Binding
	Biological Process	Protein Phosphorylation Signal Transduction Blood Coagulation Circadian Regulation Of Gene Expression Peptidyl-serine Autophosphorylation Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity Protein Targeting To Plasma Membrane	Ion Transport Positive Regulation Of Signal Transduction Ion Transmembrane Transport
Pathways		Metabolism of nitric oxide Platelet homeostasis Ca2+ pathway eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nitric oxide stimulates guanylate cyclase cGMP effects Signaling by Wnt beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Height ( 19343178 23563607 18391951) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		6 interactors: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS	33 interactors: ACD ACTA1 ACTB ACTC1 ARHGEF15 ATXN1 CDK7 DAZAP2 FHL3 FXR2 GOLGA2 KRTAP4-2 LZTS2 MDFI PLSCR1 POT1 PRKAR2B PRKG1 PRKG2 PSMA3 REL RHOXF2 SEPT3 SPRY2 TCF4 TERF1 THAP1 TINF2 TRIM27 TRIP13 ZBTB9 ZC2HC1A ZYX
Entrez ID		5593	3927
HPRD ID		09034	04229
Ensembl ID		ENSG00000138669	ENSG00000002834
Uniprot IDs		Q13237	B4DGQ0 B4DIC4 Q14847
PDB IDs			3I35
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Aorta Smooth Muscle Tissue Morphogenesis Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Tetrahydrobiopterin Biosynthetic Process Glucocorticoid Receptor Signaling Pathway Tonic Smooth Muscle Contraction Bleb Assembly Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Lysosome	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Organelle Organization Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Regulation Of Telomerase Activity Cellular Component Assembly Telomere Maintenance Negative Regulation Of Transferase Activity Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Nitrogen Compound Metabolic Process Regulation Of DNA Replication Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Cellular Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Cellular Process Cell Cycle Process Skeletal Muscle Thin Filament Assembly Positive Regulation Of Telomerase Activity Mitotic Cell Cycle Regulation Of Protein Metabolic Process Skeletal Myofibril Assembly Negative Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Positive Regulation Of Transferase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Actin Cytoskeleton Organization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Regulation Of Chromosome Organization Actin Filament-based Process Positive Regulation Of Organelle Organization Blood Coagulation Mitotic Cell Cycle Process Hemostasis Chromosome Organization
Tagcloud ?		adamts17 arrays besides bioinformatics bmp3 causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic rodents segregating segregation short shox stature trait tulp4	already axis colonization correlates cytoskeletal deaths distant effectors epithelia hnscc inhibits integrated metastasis metastatic mir mirna multilayered neck nuak1 organs postextravasation prometastatic reactivation reconstitution remodeling sparc suppressing triggers underpins
Tagcloud (Difference) ?		adamts17 arrays besides bioinformatics bmp3 causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic rodents segregating segregation short shox stature trait tulp4	already axis colonization correlates cytoskeletal deaths distant effectors epithelia hnscc inhibits integrated metastasis metastatic mir mirna multilayered neck nuak1 organs postextravasation prometastatic reactivation reconstitution remodeling sparc suppressing triggers underpins
Tagcloud (Intersection) ?