PRKG2 and MYLK

Number of citations of the paper that reports this interaction (PMID 6547441)
20

Data Source:
HPRD (in vitro)

		PRKG2	MYLK
Gene Name		protein kinase, cGMP-dependent, type II	myosin light chain kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane	Stress Fiber Cytoplasm Cytosol Cell-cell Junction Lamellipodium Cleavage Furrow Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Protein Homodimerization Activity	Actin Binding Calmodulin-dependent Protein Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Signal Transduction Blood Coagulation Circadian Regulation Of Gene Expression Peptidyl-serine Autophosphorylation Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity Protein Targeting To Plasma Membrane	Protein Phosphorylation Muscle Contraction Smooth Muscle Contraction Actin Filament Organization Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing
Pathways		Metabolism of nitric oxide Platelet homeostasis Ca2+ pathway eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nitric oxide stimulates guanylate cyclase cGMP effects Signaling by Wnt beta-catenin independent WNT signaling	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Height ( 19343178 23563607 18391951) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		6 interactors: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS	13 interactors: ACTA1 ACTC1 CALM1 CAMK2G CTTN GOPC MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC
Entrez ID		5593	4638
HPRD ID		09034	02952
Ensembl ID		ENSG00000138669	ENSG00000065534
Uniprot IDs		Q13237	B4DUE3 Q15746 Q6P2N0
PDB IDs			2CQV 2K0F 2YR3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Aorta Smooth Muscle Tissue Morphogenesis Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Tetrahydrobiopterin Biosynthetic Process Glucocorticoid Receptor Signaling Pathway Tonic Smooth Muscle Contraction Bleb Assembly Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Lysosome	Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Innate Immune Response Fc Receptor Signaling Pathway Wound Healing Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity Response To Abiotic Stimulus Actin Filament-based Process Actin-myosin Filament Sliding Muscle Filament Sliding Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Response To Wounding Cell Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Cellular Component Assembly Epidermal Growth Factor Receptor Signaling Pathway Anatomical Structure Development Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Actin-mediated Cell Contraction Immune Response Regulation Of Kinase Activity Protein Phosphorylation Blood Coagulation Hemostasis Defense Response Regulation Of Intracellular Transport Caveolin-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Positive Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Peptidyl-serine Autophosphorylation Vesicle-mediated Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Muscle Contraction
Tagcloud ?		adamts17 arrays besides bioinformatics bmp3 causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic rodents segregating segregation short shox stature trait tulp4	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		adamts17 arrays besides bmp3 causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic rodents segregating segregation short shox stature trait tulp4	bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?		bioinformatics