PFKFB1 and DDIT4L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PFKFB1	DDIT4L
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	DNA damage inducible transcript 4 like
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex	Cytoplasm
	Molecular Function	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Identical Protein Binding	Protein Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Carbohydrate Phosphorylation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate	Negative Regulation Of Signal Transduction
Pathways		PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs		D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Alcohol consumption (drinks per week) ( 30643258) Nose size ( 27182965)
Interacting Genes		14 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688	155 interacting genes: ABCB11 ACY3 AFMID AIDA AKT1 ARK2N ARPIN BAG4 BANF2 BCL2L14 BID C14orf119 C19orf25 C5orf22 CABP5 CALCOCO2 CALM1 CALM2 CALM3 CATIP CCNK CDA CDKN2D CDPF1 CHMP1A CLIC3 CLK2 CLK3 CPNE7 CRLF3 CRYBB1 DBI DNPH1 DUSP23 DUSP29 EIF4A3 EIF4EBP1 EIF4H EPHB6 EXOSC1 EXOSC5 EXOSC8 FAAP20 FADD FAM200C FHIT FHL2 FKBP6 FLNA GADD45G GEMIN6 GPKOW GRB2 GUCA1A HDAC7 HMG20A HSPB7 IL36RN IMPDH1 KANK2 KCTD9 KDM8 KRT34 KRTAP5-6 LENG1 LGALS14 LGALSL LMO1 LRATD2 LSM3 LSM5 LSM7 MAP3K7CL MAPRE2 MAPRE3 MEMO1 MIEN1 MKRN3 MLX MORF4L2 MT1M MYG1 MYLIP NAA10 NAV1 NEK6 NGB NHLRC4 NME7 NQO2 NR2C2AP NUDT2 NUDT22 NXT2 PARVG PCBP3 PDE4C PFKFB1 PLSCR4 PM20D2 PMVK PPCDC PPIL1 PPP1R27 PRKAB2 PRPF40A PSMA1 PSMB9 PTS PUF60 RAB32 RFC5 RFPL3 RPIA RPL22 RPRD1B SCOC SEC22A SEPTIN1 SEPTIN3 SEPTIN5 SH3BGRL3 SNRPA SNRPG SREK1IP1 STK16 STK4 SULT2B1 TBC1D22B TCL1A TCP11L1 TEKT4 TEX14 TFPT TNS2 TOLLIP TRIM73 TSEN15 TSSK3 TTC5 TXN TXNL4A TYW3 UBASH3A UBTFL1 VBP1 VCX2 VPS26C YES1 YOD1 YPEL5 ZNF593 ZNF76 ZNF765 ZSCAN23
Entrez ID		5207	115265
HPRD ID		02411	09663
Ensembl ID		ENSG00000158571	ENSG00000145358
Uniprot IDs		I1Z9G4 P16118	Q96D03
PDB IDs		1K6M
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Cell Response To Fluid Shear Stress Positive Regulation Of Mitotic Cell Cycle Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Extrinsic Component Of Membrane Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Phosphorylation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Postsynapse Peptidyl-serine Phosphorylation Response To Nerve Growth Factor Cellular Response To Fluid Shear Stress Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Gluconeogenesis Positive Regulation Of Steroid Metabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Mitotic Cell Cycle Response To Fluid Shear Stress Positive Regulation Of Protein Localization Regulation Of TRNA Methylation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Negative Regulation Of Cell Communication Regulation Of Cholesterol Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Hexose Biosynthetic Process Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Transport Regulation Of Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Maturation	Protein Binding Cytoplasm Nucleus MRNA Splicing, Via Spliceosome MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Identical Protein Binding Cytosol U4/U6 X U5 Tri-snRNP Complex MRNA Processing RNA Splicing Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Lsm1-7-Pat1 Complex RNA Processing Nucleobase-containing Compound Metabolic Process Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Lsm2-8 Complex Protein Serine/threonine Kinase Activator Activity Spliceosomal Complex U6 SnRNP Protein Kinase Binding Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Nucleolar Exosome (RNase Complex) U2-type Precatalytic Spliceosome Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Nucleoplasm Titin Binding Septin Ring Septin Complex Cell Division Site Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Detection Of Calcium Ion Nucleobase-containing Compound Catabolic Process Regulation Of Cell Communication By Electrical Coupling Nuclear Exosome (RNase Complex) U2-type Prespliceosome Exosome (RNase Complex) Phosphate-containing Compound Metabolic Process Protein Phosphatase Activator Activity Microtubule Cytoskeleton Calyx Of Held U1 SnRNP RNA Metabolic Process Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Regulator Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?