PFKFB1 and ZNF276

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PFKFB1	ZNF276
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	zinc finger protein 276
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome
	Molecular Function	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Identical Protein Binding	DNA Binding Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Carbohydrate Phosphorylation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate	Regulation Of Transcription By RNA Polymerase II
Pathways		PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs		D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Brain morphology (MOSTest) ( 32665545) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		14 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688	13 interacting genes: AP1M1 ATXN1 CDC37 CIB3 FAM161A GCC1 MEOX2 MORF4L1 PFKFB1 PICK1 SEPHS1 TCEANC ZBTB8A
Entrez ID		5207	92822
HPRD ID		02411	12235
Ensembl ID		ENSG00000158571	ENSG00000158805
Uniprot IDs		I1Z9G4 P16118	I6L9I3 Q8N554
PDB IDs		1K6M
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Cell Response To Fluid Shear Stress Positive Regulation Of Mitotic Cell Cycle Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Extrinsic Component Of Membrane Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Phosphorylation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Postsynapse Peptidyl-serine Phosphorylation Response To Nerve Growth Factor Cellular Response To Fluid Shear Stress Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Gluconeogenesis Positive Regulation Of Steroid Metabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Mitotic Cell Cycle Response To Fluid Shear Stress Positive Regulation Of Protein Localization Regulation Of TRNA Methylation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Negative Regulation Of Cell Communication Regulation Of Cholesterol Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Hexose Biosynthetic Process Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Transport Regulation Of Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Maturation
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