PFKFB1

Gene Name		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Binding Identical Protein Binding Fructose-6-phosphate Binding
	Biological Process	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Energy Reserve Metabolic Process Pathogenesis Dephosphorylation Organ Regeneration Response To Insulin Positive Regulation Of Glucokinase Activity Response To Glucagon Intracellular Signal Transduction Response To Starvation Small Molecule Metabolic Process Carbohydrate Phosphorylation Response To Glucocorticoid Response To CAMP
Pathways		PP2A-mediated dephosphorylation of key metabolic factors Gluconeogenesis Glucose metabolism Integration of energy metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Glycolysis Metabolism of carbohydrates
Drugs		D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate 3-Phosphoglycerol Phosphothiophosphoric Acid-Adenylate Ester Guanosine-5\'-Triphosphate Fructose-6-Phosphate
Diseases
GWAS
Protein-protein Interactions		5 interactors: AKT1 APP MAPK3 PRKACA PRKCA
Entrez ID		5207
HPRD ID		02411
Ensembl ID		ENSG00000158571
Uniprot IDs		B4DUN5 I1Z9G4 P16118
PDB IDs		1K6M
Enriched GO Terms of Interacting Partners?		Platelet Activation Regulation Of Cellular Amino Acid Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway Wound Healing Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Cell Activation Response To Fibroblast Growth Factor Response To Wounding Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Dense Core Granule Biogenesis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Kinase Activity Innate Immune Response Regulation Of Blood Vessel Endothelial Cell Migration Histone H3-T6 Phosphorylation Positive Regulation Of Cell Cycle Apoptotic Process Positive Regulation Of Endothelial Cell Migration Programmed Cell Death Positive Regulation Of Endothelial Cell Proliferation Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Glucose Import Response To Light Stimulus Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epithelial Cell Migration Response To Interleukin-1 Regulation Of Endothelial Cell Proliferation Immune Response Regulation Of Phosphorylation Protein Phosphorylation Defense Response Response To Radiation Regulation Of Glucose Transport Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Endothelial Cell Migration
Tagcloud ?