PFKFB1 and ZNF688

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PFKFB1	ZNF688
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	zinc finger protein 688
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex	Nucleus
	Molecular Function	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Identical Protein Binding	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Carbohydrate Phosphorylation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate	Regulation Of DNA-templated Transcription
Pathways		PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	Generic Transcription Pathway
Drugs		D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		14 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688	111 interacting genes: ABI2 AIRIM ANKRD11 BEND5 BLZF1 BOLA2 BOLA2B CADPS CALCOCO2 CARD9 CATSPER1 CBY2 CCDC102B CCDC136 CCDC33 CCDC57 CCNC CDKN2D CDR2L CEP44 CEP70 CEP72 CIB3 CRX DEF6 EHMT2 FAM90A1 FBXO7 FCHO1 FHL5 GEM GLYCTK GMPPA GOLGA2 GPANK1 GPRASP2 HMBOX1 HNRNPK HOMEZ HOXA1 HSF2BP IGFN1 IHO1 KHDRBS2 KHDRBS3 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-9 KRTAP12-2 KRTAP4-2 LDOC1 LMO1 LMO2 MAGED1 MDFI MEOX2 MID2 MIPOL1 MKRN3 MYOZ3 NCK2 NEK6 NFU1 NOTCH2NLA OSTF1 PCBD1 PFKFB1 PHF1 PIH1D2 PLSCR1 PNMA1 PNMA2 POLR1C PSMA3 PSMB1 PSTPIP1 RCOR3 REL RFX6 RINT1 RPGRIP1 SCNM1 SMARCB1 SPAG5 SSX2IP TADA2A TCEANC TCF12 TCF4 TCP11 TEKT4 TENT5B TLE5 TMCC2 TNS2 TRAF1 TRAF2 TRAF4 TRIM23 TRIM27 TRIP6 TTC19 USHBP1 WWP2 ZC4H2 ZGPAT ZNF330
Entrez ID		5207	146542
HPRD ID		02411	14070
Ensembl ID		ENSG00000158571	ENSG00000229809
Uniprot IDs		I1Z9G4 P16118	A0A0S2Z5X4 A0A0S2Z633 P0C7X2
PDB IDs		1K6M
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Cell Response To Fluid Shear Stress Positive Regulation Of Mitotic Cell Cycle Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Extrinsic Component Of Membrane Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Phosphorylation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Postsynapse Peptidyl-serine Phosphorylation Response To Nerve Growth Factor Cellular Response To Fluid Shear Stress Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Gluconeogenesis Positive Regulation Of Steroid Metabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Mitotic Cell Cycle Response To Fluid Shear Stress Positive Regulation Of Protein Localization Regulation Of TRNA Methylation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Negative Regulation Of Cell Communication Regulation Of Cholesterol Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Hexose Biosynthetic Process Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Transport Regulation Of Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Maturation	Protein Binding Identical Protein Binding Keratin Filament Nucleus Intermediate Filament Signaling Adaptor Activity Cytoskeleton Thioesterase Binding Transcription Coactivator Activity Microtubule Organizing Center Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?