PFKFB1 and VWC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PFKFB1	VWC2
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	von Willebrand factor C domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Extracellular Matrix AMPA Glutamate Receptor Complex Synapse Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Identical Protein Binding	Molecular_function Protein Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Carbohydrate Phosphorylation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate	Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Neuron Differentiation Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways		PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs		D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Age at first birth ( 34211149) Blood protein levels ( 30072576) Body mass index ( 25673413 28892062) Lung cancer in never smokers ( 28604730) Neurological blood protein biomarker levels ( 31320639) Post bronchodilator FEV1/FVC ratio ( 26634245) Pursuit maintenance gain ( 29064472) Serum thyroid-stimulating hormone levels ( 25436638) tricyclic pyrone compound response (IC50) ( 33610756)
Interacting Genes		14 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688	57 interacting genes: ABHD15 ADAMTSL4 ATPAF2 CAMLG CATSPER1 CNNM3 CRY2 CYSRT1 ENKD1 FAM90A1 FBXW5 FUCA2 GET3 GNE HAPLN2 HOXA1 HPCA HPCAL1 KANK2 KPRP KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 LCE1A LCE1C LCE1F LCE2C LCE2D LCE3A LCE3D LCE3E LCE4A LCE5A NTM OTX1 PFKFB1 POU4F2 PRPF31 SCNM1 SGTB SHFL SPRY1 TRAPPC14 UBQLN1 UBQLN2 VASN YY1 ZNF319 ZNF417 ZNF490 ZNF497 ZNF587 ZNF774 ZNF837
Entrez ID		5207	375567
HPRD ID		02411	18271
Ensembl ID		ENSG00000158571	ENSG00000188730
Uniprot IDs		I1Z9G4 P16118	Q2TAL6
PDB IDs		1K6M
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Cell Response To Fluid Shear Stress Positive Regulation Of Mitotic Cell Cycle Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Extrinsic Component Of Membrane Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Phosphorylation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Postsynapse Peptidyl-serine Phosphorylation Response To Nerve Growth Factor Cellular Response To Fluid Shear Stress Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Gluconeogenesis Positive Regulation Of Steroid Metabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Mitotic Cell Cycle Response To Fluid Shear Stress Positive Regulation Of Protein Localization Regulation Of TRNA Methylation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Negative Regulation Of Cell Communication Regulation Of Cholesterol Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Hexose Biosynthetic Process Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Transport Regulation Of Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Maturation	Epidermis Development Keratinization Tissue Development Protein Binding Intermediate Filament GET Complex Identical Protein Binding Keratin Filament
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