AHSG and FBXO2

Number of citations: 0 (PubMedID 12140560)
Data Source: HPRD (in vivo)

		AHSG	FBXO2
Name		alpha 2-HS glycoprotein	F-box protein 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome Blood Microparticle	Cytoplasm Endoplasmic Reticulum Cytosol Membrane SCF Ubiquitin Ligase Complex Dendritic Spine Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Kinase Inhibitor Activity	Amyloid-beta Binding Ubiquitin-protein Transferase Activity Protein Binding Carbohydrate Binding Denatured Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Skeletal System Development Ossification Pinocytosis Acute-phase Response Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis	Proteolysis Ubiquitin-dependent Protein Catabolic Process Glycoprotein Catabolic Process Negative Regulation Of Cell Population Proliferation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Protein Modification Process ERAD Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
GWAS		Activated partial thromboplastin time ( 22703881 ) Blood protein levels ( 30072576 )	No GWAS studies recorded
Interacting Genes		9 interacting genes: CDC42 DCN FBXO2 FBXW7 GRB2 HSP90AA1 INSR RRAS2 VKORC1	16 interacting genes: AHSG BACE1 BRAP ECPAS IGH ITGB1 PAX4 PFDN6 SKP1 STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 VSTM1
Entrez ID		197	26232
HPRD ID		00727	06171
Ensembl ID		ENSG00000145192	ENSG00000116661
Uniprot IDs		C9JV77 P02765	Q9UK22
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Organelle Organization GTP Binding Insulin Receptor Substrate Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Assembly Neuron Projection Organization Regulation Of Lamellipodium Assembly Dendritic Spine Organization Postsynapse Organization Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Post-translational Protein Modification Small GTPase-mediated Signal Transduction Regulation Of Lamellipodium Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Guanyl-nucleotide Exchange Factor Adaptor Activity CTP Binding DATP Binding Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Receptor Internalization Regulation Of Cell Migration Neuronal Cell Body GBD Domain Binding Storage Vacuole Identical Protein Binding Lysosomal Lumen Positive Regulation Of Protein Polymerization Protein Phosphatase Binding Insulin Receptor Signaling Pathway Grb2-EGFR Complex Ras Protein Signal Transduction Regulation Of Protein Catabolic Process Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Amyloid-beta Binding Denatured Protein Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Monoubiquitination Proteolysis Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Ligase Complex Ubiquitin Protein Ligase Activity Protein Autoubiquitination Protein Modification Process Proteasomal Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Vasoconstriction Positive Regulation Of Protein Ubiquitination Catabolic Process Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Folding Chaperone Complex Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transferase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Myoblast Fate Specification Integrin Alpha7-beta1 Complex Nucleoplasm Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Chaperone-mediated Protein Complex Assembly Multivesicular Body Golgi-associated Vesicle Lumen Negative Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Integrin Alpha6-beta1 Complex Regulation Of Vasoconstriction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Positive Regulation Of Programmed Cell Death Integrin Alpha1-beta1 Complex