DUSP26 and RET

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		DUSP26	RET
Description		dual specificity phosphatase 26	ret proto-oncogene
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Extracellular Exosome	Endosome Plasma Membrane Endosome Membrane Membrane Axon Receptor Complex Plasma Membrane Protein Complex
	Molecular Function	P53 Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Phosphatase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Negative Regulation Of ERK1 And ERK2 Cascade	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Posterior Midgut Development Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neuron Maturation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs GDF15-GFRAL Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			RAF/MAP kinase cascade RET signaling NPAS4 regulates expression of target genes Formation of the nephric duct Formation of the ureteric bud
Drugs			Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib
Diseases			Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Thyroid cancer Renal agenesis and Renal adysplasia
GWAS		Body mass index ( 25673413 28892062) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Metabolite levels ( 23823483) Morning person ( 30696823) Reading disability ( 32108986) Self-reported risk-taking behaviour ( 30271922)	Blood protein levels ( 30072576) Cannabis dependence symptom count ( 27028160) Hirschsprung disease ( 19196962 25310821 27702942 29379196 30031151) Smoking behaviour (cigarettes smoked per day) ( 31089300)
Interacting Genes		11 interacting genes: CALCOCO2 CARD10 EPHA2 EPHA7 GOLGA6L9 GRIPAP1 HSF4 IGF1R KRT27 PTK7 RET	46 interacting genes: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 DUSP26 ERBB2 FBXO7 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG LRRK1 MAPK1 MAPK14 MAPK3 MAPK8 NEDD4 NOTCH2NLA NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRA PTPRF PTPRR SHC1 SHC3 SHC4 SNCA SRC STAT3 TLN1
Entrez ID		78986	5979
HPRD ID		14421	01266
Ensembl ID		ENSG00000133878	ENSG00000165731
Uniprot IDs		Q9BV47	A0A087WWB1 A0AAQ5BH28 B4DGX8 P07949
PDB IDs		2E0T 4B04 4HRF 5GTJ	2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U 4CKI 4CKJ 4UX8 5AMN 5FM2 5FM3 6FEK 6GL7 6I82 6I83 6NE7 6NEC 6NJA 6Q2J 6Q2N 6Q2O 6Q2R 6Q2S 6VHG 7DU8 7DU9 7DUA 7JU5 7JU6 7NZN 7RUN
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Tissue Morphogenesis Protein Kinase Activity Axon Guidance Receptor Activity Ephrin Receptor Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Axon Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Complex Positive Regulation Of Protein-containing Complex Disassembly Neuron Projection Guidance Axon Guidance Growth Factor Binding Positive Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Notochord Cell Development Kinase Activity Ephrin Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Projection Organization Extrinsic Component Of Postsynaptic Early Endosome Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Retinoic Acid ATP Binding Anatomical Structure Morphogenesis Axial Mesoderm Formation Neuronal Cell Body Posterior Midgut Development Negative Regulation Of Receptor Clustering Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Negative Regulation Of Lymphangiogenesis Notochord Formation Plasma Membrane Bounded Cell Projection Organization Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Insulin Receptor Activity Response To Retinoic Acid Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Regulation Of Protein Localization To Plasma Membrane Regulation Of Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Insulin Receptor Complex	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Intracellular Signal Transduction Regulation Of Signal Transduction Neurotrophin TRKA Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Response To Growth Factor Positive Regulation Of Signal Transduction ERBB2 Signaling Pathway Plasma Membrane Ephrin Receptor Binding Regulation Of MAPK Cascade Focal Adhesion Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Cytoplasm MAP Kinase Activity Negative Regulation Of Immune System Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Domain Specific Binding Schwann Cell Development Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cell Migration Protein Phosphatase Binding Protein Tyrosine Phosphatase Activity Response To Epidermal Growth Factor Positive Regulation Of Cell Motility Regulation Of Immune System Process Negative Regulation Of Signal Transduction Positive Regulation Of Locomotion Stress-activated MAPK Cascade Insulin Receptor Binding Regulation Of Locomotion
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