RAB6A and RABGAP1

Number of citations of the paper that reports this interaction (PubMedID 10202141)
59

Data Source:
HPRD (two hybrid, in vitro)

		RAB6A	RABGAP1
Description		RAB6A, member RAS oncogene family	RAB GTPase activating protein 1
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GO Annotations	Cellular Component	Golgi Membrane Acrosomal Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Secretory Granule Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Ciliary Basal Body Extracellular Exosome Endosome To Plasma Membrane Transport Vesicle	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Associated Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding Myosin V Binding	GTPase Activator Activity Protein Binding Tubulin Binding Small GTPase Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Peptidyl-cysteine Methylation Antigen Processing And Presentation Neuron Projection Development Protein Localization To Golgi Apparatus Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Minus-end-directed Organelle Transport Along Microtubule Protein Localization To Golgi Membrane	Regulation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Pre-NOTCH Processing in Golgi Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	TBC/RABGAPs
Drugs
Diseases
GWAS		Dimensional psychopathology (Cognitive) ( 29496196) Obesity-related traits ( 23251661)	Birth weight ( 31043758) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878)
Interacting Genes		23 interacting genes: BICD1 BICD2 CHM CHML DCTN1 ERC1 FKBP2 GDI1 GOLGA1 GOLGA2 GOLGA4 GORAB KIF20A OCRL PMM1 RAB7A RABAC1 RABGAP1 RABGGTB SYTL5 TIAM1 TMEM132D TMF1	10 interacting genes: CARM1 DISC1 GABARAPL1 MAP1LC3A RAB4A RAB6A RAB6B SENP1 SENP5 STAT3
Entrez ID		5870	23637
HPRD ID		01543	06575
Ensembl ID		ENSG00000175582	ENSG00000011454
Uniprot IDs		A0A024R5J5 P20340 Q53ET8	B7Z2B4 Q9Y3P9
PDB IDs		1YZQ 2GIL 3BBP 3CWZ 4DKX 5LEF	4NC6
Enriched GO Terms of Interacting Partners?		Small GTPase Binding Golgi Apparatus Vesicle-mediated Transport Rab-protein Geranylgeranyltransferase Complex Protein Geranylgeranylation Cellular Localization Intracellular Transport Protein Prenylation Microtubule Anchoring At Microtubule Organizing Center Protein Transport GDP-dissociation Inhibitor Activity Establishment Of Localization In Cell Establishment Of Protein Localization Microtubule Anchoring Intracellular Protein Localization Minus-end-directed Organelle Transport Along Microtubule Rab Geranylgeranyltransferase Activity GTPase Activator Activity Golgi Vesicle Transport Organelle Assembly Cytosol Trans-Golgi Network Cytoplasm Positive Regulation Of Axonogenesis Microtubule-based Movement Dynactin Binding Microtubule Cytoskeleton Organization Retrograde Transport, Endosome To Golgi Dynein Complex Binding Retromer Complex Cytoskeletal Anchor Activity Small GTPase-mediated Signal Transduction Establishment Of Organelle Localization Microtubule-based Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytosolic Transport Maintenance Of Synapse Structure Vesicle-mediated Transport To The Plasma Membrane Cytoplasmic Vesicle Mitotic Spindle Regulation Of Axonogenesis Microtubule Associated Complex Positive Regulation Of Axon Extension GTPase Binding Synaptic Vesicle Recycling Via Endosome Neuronal Cell Body Regulation Of Microtubule Cytoskeleton Organization Golgi Membrane Transport Along Microtubule Centrosome	Glutamatergic Synapse Protein Localization To Golgi Membrane Cellular Response To Nitrogen Starvation SUMO-specific Endopeptidase Activity Protein Desumoylation DeSUMOylase Activity Ciliary Basal Body Phosphatidylethanolamine Binding Myosin V Binding Protein Localization To Golgi Apparatus Presynaptic Cytosol Postsynaptic Cytosol Intra-Golgi Vesicle-mediated Transport Protein Localization To Organelle Endomembrane System Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Regulation Of Erythrocyte Differentiation Autophagosome Maturation Protein Sumoylation Autophagosome Membrane Mitophagy Peptidyl-cysteine Methylation GTPase Activity Microtubule Autophagy Of Mitochondrion Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome GTP Binding Cytoplasmic Vesicle Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Histone H3R2 Methyltransferase Activity Histone H3R17 Methyltransferase Activity Autophagosome Hydrolase Activity Antigen Processing And Presentation Retrograde Transport, Endosome To Golgi Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Histone Arginine N-methyltransferase Activity Autophagosome Organization Autophagosome Assembly Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Regulation Of Definitive Erythrocyte Differentiation Intracellular Protein Localization Positive Regulation Of MRNA Catabolic Process Protein Modification By Small Protein Removal Phospholipid Binding Minus-end-directed Organelle Transport Along Microtubule
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