RNF220

Description		ring finger protein 220
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Lamina Nucleoplasm Cytoplasm Protein-containing Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Noradrenergic Neuron Development Protein Monoubiquitination Protein Ubiquitination Dorsal/ventral Neural Tube Patterning Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Interleukin-6 levels ( 22205395) Resting heart rate ( 27798624 29769521)
Interacting Genes		9 interacting genes: DYRK1A GOPC PELI2 PTGER4 SIN3B UBE2D2 UBE2D3 UBE2L3 USP7
Entrez ID		55182
HPRD ID		13336
Ensembl ID		ENSG00000187147
Uniprot IDs		Q5VTB9
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Modification Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Ubiquitin-protein Transferase Activity Regulation Of Protein Targeting To Mitochondrion Histone H3T45 Kinase Activity Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Anion Channel Activity Protein Autoubiquitination Ubiquitin Protein Ligase Activity Regulation Of Protein Localization Transferase Activity Negative Regulation Of Eosinophil Migration Y Chromosome Autosome Protein Metabolic Process Negative Regulation Of Integrin Activation Protein K48-linked Ubiquitination Symbiont-mediated Disruption Of Host Cell PML Body DNA Repair Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein-containing Complex Assembly Prostaglandin Receptor Activity Proteolysis Regulation Of Establishment Of Protein Localization X Chromosome Negative Regulation Of Heterochromatin Formation Prostaglandin E Receptor Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Toll Signaling Pathway Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi ATP Binding Negative Regulation Of Cellular Extravasation Proteolysis Involved In Protein Catabolic Process Regulation Of Heterochromatin Formation Ubiquitin-protein Transferase Activator Activity Monoubiquitinated Protein Deubiquitination
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