RNF220 and GOPC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RNF220	GOPC
Description		ring finger protein 220	golgi associated PDZ and coiled-coil motif containing
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Lamina Nucleoplasm Cytoplasm Protein-containing Complex Postsynapse Glutamatergic Synapse	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex Cell Projection Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding Transmembrane Transporter Binding Molecular Sequestering Activity
	Biological Process	Noradrenergic Neuron Development Protein Monoubiquitination Protein Ubiquitination Dorsal/ventral Neural Tube Patterning Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Transcription Regulatory Region DNA Binding	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Negative Regulation Of Anion Channel Activity Protein Transport Apical Protein Localization Negative Regulation Of Protein Localization To Cell Surface
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Interleukin-6 levels ( 22205395) Resting heart rate ( 27798624 29769521)	Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Mild obesity-related type 2 diabetes ( 34737425) Night sleep phenotypes ( 27126917)
Interacting Genes		9 interacting genes: DYRK1A GOPC PELI2 PTGER4 SIN3B UBE2D2 UBE2D3 UBE2L3 USP7	71 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CCDC102B CCDC198 CD300C CDKN2C CEBPA CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GEM GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 OSBP2 PARK7 PID1 PPP1R18 PWWP3A RALGAPB RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SNX31 SPATA8 SSTR5 STARD3 STX6 TGFBR2 UBE3A VIM VTN ZBTB49 ZDHHC1 ZNF564 ZNF581 ZNF587 ZNF835 ZSCAN1
Entrez ID		55182	57120
HPRD ID		13336	06024
Ensembl ID		ENSG00000187147	ENSG00000047932
Uniprot IDs		Q5VTB9	Q9HD26
PDB IDs			2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7 6V84 6XNJ 7JZO 7JZP 7JZQ 7JZR
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Modification Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Ubiquitin-protein Transferase Activity Regulation Of Protein Targeting To Mitochondrion Histone H3T45 Kinase Activity Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Anion Channel Activity Protein Autoubiquitination Ubiquitin Protein Ligase Activity Regulation Of Protein Localization Transferase Activity Negative Regulation Of Eosinophil Migration Y Chromosome Autosome Protein Metabolic Process Negative Regulation Of Integrin Activation Protein K48-linked Ubiquitination Symbiont-mediated Disruption Of Host Cell PML Body DNA Repair Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein-containing Complex Assembly Prostaglandin Receptor Activity Proteolysis Regulation Of Establishment Of Protein Localization X Chromosome Negative Regulation Of Heterochromatin Formation Prostaglandin E Receptor Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Toll Signaling Pathway Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi ATP Binding Negative Regulation Of Cellular Extravasation Proteolysis Involved In Protein Catabolic Process Regulation Of Heterochromatin Formation Ubiquitin-protein Transferase Activator Activity Monoubiquitinated Protein Deubiquitination	Response To Lipid Phagocytic Vesicle PDZ Domain Binding Golgi-associated Vesicle Membrane Response To Xenobiotic Stimulus Positive Regulation Of Cellular Component Biogenesis Phagocytosis, Engulfment Response To Vitamin Negative Regulation Of Cell Population Proliferation Regeneration Liver Development Response To Hormone Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Positive Regulation Of Reactive Oxygen Species Metabolic Process Glutamatergic Synapse Transcription Factor AP-1 Complex Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Scaffold Protein Binding SMAD Protein Signal Transduction Postsynapse To Nucleus Signaling Pathway Response To Muramyl Dipeptide Membrane Hyperpolarization Negative Regulation Of Skeletal Muscle Cell Differentiation Myeloid Leukocyte Differentiation Hormone-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Stem Cell Proliferation Signal Transduction Organic Hydroxy Compound Transport Integrated Stress Response Signaling Synaptic Signaling Via Neuropeptide Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Adhesion Molecule Production
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