CLIP1 and CLIP4

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		CLIP1	CLIP4
Name		CAP-Gly domain containing linker protein 1	CAP-Gly domain containing linker protein family member 4
Structure
GO Annotations	Cellular Component	Kinetochore Ruffle Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Cell Cortex Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Microtubule Plus-end Cell Projection Macropinosome	Nucleus Cell Cortex Microtubule Plus-end
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Identical Protein Binding Metal Ion Binding Microtubule Plus-end Binding	Protein Binding Microtubule Plus-end Binding
	Biological Process	Mitotic Cell Cycle Microtubule Bundle Formation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization	Cytoplasmic Microtubule Organization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases activate IQGAPs RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Signaling by LTK in cancer	None
GWAS		A body shape index ( 34021172 ) Adiponectin levels ( 31178129 ) Body fat percentage and HDL-C (pairwise) ( 33619380 ) Body mass index ( 25673413 26961502 ) Body mass index and HDL-C (pairwise) ( 33619380 ) Chronotype ( 30696823 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hip circumference ( 25673412 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Walking pace ( 33128006 ) Weight ( 28552196 )	Metabolite levels ( 23823483 )
Novel Interactors		None recorded	4 novel interactors: PCARE SPDYA TOGARAM2 TRMT61B
Interacting Genes		13 interacting genes: BIN1 CALM1 CLASP2 CLIP4 DCTN1 IQGAP1 MAPRE2 MTOR PAFAH1B1 REL TSC22D2 TUBA1A TUBB	37 interacting genes: APP CDK5RAP2 CLIP1 CMYA5 DCAF6 DES DST DYNC2LI1 GLP1R HSF2BP JAKMIP2 KIF1B KIFC3 LZTS2 MAGEA12 MAP7 MAP7D1 MEOX2 MYBPC1 MYH3 PDE4DIP PEG10 RPS13 RPS27L RUNX1 SIX2 SON TACC3 TAF1 TNNT1 TNNT3 TPM1 TRIM32 TRIP13 TTN TULP3 ZNF114
Entrez ID		6249	79745
HPRD ID		01568	08634
Ensembl ID		ENSG00000130779	ENSG00000115295
Uniprot IDs		B3KXA5 P30622	A0A8I5KXU9 A0A8I5QKP4 A0A8I5QKV0 A8K6D0 B7Z936 G3XAK3 Q8N3C7
PDB IDs		2CP5 2CP6 2E3H 2E3I 2E4H 2HQH 2QK0 3E2U 3RDV 8WHH 8WHI	2Z0W
GO Terms Enriched among Interactors		Microtubule Microtubule Plus-end Binding Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Cytoplasmic Microtubule Cell Leading Edge Cell Cortex Cell Division Microtubule Plus-end Microtubule-based Process Regulation Of Cytoskeleton Organization Neuromuscular Process Cytoskeleton Establishment Of Mitotic Spindle Localization Protein-containing Complex Binding Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Epithelial Cell Migration Organelle Assembly Cellular Component Assembly Establishment Of Spindle Localization Cytoskeleton-dependent Intracellular Transport Spindle Localization Organelle Organization Organelle Localization Regulation Of Epithelial Cell Migration Spindle Positive Regulation Of Keratinocyte Migration Microtubule Binding Microtubule Organizing Center Organization Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Protein Polymerization Regulation Of Microtubule-based Process Establishment Of Organelle Localization Spindle Assembly Establishment Of Localization In Cell Regulation Of Microtubule Polymerization Or Depolymerization Nuclear Membrane Disassembly Regulation Of Synapse Organization Membrane Disassembly Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cellular Component Organization Regulation Of Organelle Organization Response To Calcium Ion Mitotic Spindle Microtubule Anchoring Mitotic Cell Cycle Regulation Of Supramolecular Fiber Organization	Cytoskeleton Organization Sarcomere Organization Organelle Organization Microtubule-based Process Microtubule Cytoskeleton Organization Actomyosin Structure Organization Microtubule Skeletal Muscle Contraction Striated Muscle Contraction Microtubule Binding Muscle Filament Sliding Muscle Contraction Actin-myosin Filament Sliding Centrosome Actin Cytoskeleton Organization Cytoskeleton Microtubule Plus-end Microtubule Cytoskeleton Muscle System Process M Band Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Microtubule Polymerization Actin-mediated Cell Contraction Female Meiosis I Structural Constituent Of Muscle Troponin Complex Myofibril Male Meiotic Nuclear Division Regulation Of Supramolecular Fiber Organization Actin Filament-based Movement Contractile Muscle Fiber Tropomyosin Binding Regulation Of Microtubule Polymerization Cytoskeletal Protein Binding Regulation Of Microtubule Cytoskeleton Organization Transport Along Microtubule Meiotic Nuclear Division Female Meiotic Nuclear Division Axo-dendritic Transport Positive Regulation Of Cytoskeleton Organization Supramolecular Fiber Organization Retrograde Axonal Transport Microtubule Plus-end Binding Positive Regulation Of Protein Polymerization Cytoskeleton-dependent Intracellular Transport Myosin Filament Nuclear Division Regulation Of Cytoskeleton Organization Amyloid-beta Complex