ZNF227 and CSNK1E

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ZNF227	CSNK1E
Description		zinc finger protein 227	casein kinase 1 epsilon
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol Growth Cone Neuronal Cell Body Ribonucleoprotein Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	DNA Repair Protein Phosphorylation Endocytosis Signal Transduction Intracellular Protein Localization Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Circadian Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Circadian Behavior Negative Regulation Of Small GTPase Mediated Signal Transduction Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		Generic Transcription Pathway	WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A AURKA Activation by TPX2 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs			Seliciclib Umbralisib
Diseases
GWAS			Keratoconus ( 31855235) Mastocytosis ( 32752121)
Interacting Genes		7 interacting genes: APP CDKN2A CEP70 CSNK1E GSK3B RPS6KA6 UMPS	61 interacting genes: AKAP17A AKAP9 ANKRD6 APC APP ARHGEF1 AXIN1 AXIN2 BBS10 BHLHE41 BID BMAL1 CADM4 CCDC14 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HAUS7 HES1 KAT7 NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRD RAD17 RAD54B RBX1 RORA RORC SNCA SOCS3 TAFAZZIN TAOK1 TLE5 TNS2 TRIM2 TRIM3 WDCP YAP1 ZMYND8 ZNF227 ZNF618
Entrez ID		7770	1454
HPRD ID		15752	02919
Ensembl ID		ENSG00000131115	ENSG00000213923
Uniprot IDs		B7Z6M2 Q86WZ6	P49674 Q5U045
PDB IDs			4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Amyloid Fibril Formation Regulation Of Protein Localization To Nucleus Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process NF-kappaB Binding Regulation Of Canonical Wnt Signaling Pathway Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Export From Nucleus Response To Nerve Growth Factor Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Amyloid-beta Complex Regulation Of Wnt Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Protein Localization Cytosol Regulation Of Intracellular Signal Transduction P53 Binding Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Microtubule Anchoring At Centrosome Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TOR Signaling Regulation Of Membrane Potential Regulation Of Protein Transport Positive Regulation Of Protein Localization Regulation Of Calcium-mediated Signaling Negative Regulation Of Multicellular Organismal Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Mitotic Cell Cycle	Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Signal Transduction Rhythmic Process Photoperiodism Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Radiation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Circadian Rhythm Regulation Of Canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process E-box Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Cytoplasm Signal Transduction Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription
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