ZNF227 and RPS6KA6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ZNF227	RPS6KA6
Description		zinc finger protein 227	ribosomal protein S6 kinase A6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Signal Transduction Central Nervous System Development DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development
Pathways		Generic Transcription Pathway	Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation
Drugs			Fostamatinib
Diseases
GWAS
Interacting Genes		7 interacting genes: APP CDKN2A CEP70 CSNK1E GSK3B RPS6KA6 UMPS	28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746
Entrez ID		7770	27330
HPRD ID		15752	02250
Ensembl ID		ENSG00000131115	ENSG00000072133
Uniprot IDs		B7Z6M2 Q86WZ6	A0AAU7BMN7 A0AAU7BMR9 A0AAU7BMT2 A0AAU7BN28 Q9UK32
PDB IDs			6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Amyloid Fibril Formation Regulation Of Protein Localization To Nucleus Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process NF-kappaB Binding Regulation Of Canonical Wnt Signaling Pathway Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Export From Nucleus Response To Nerve Growth Factor Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Amyloid-beta Complex Regulation Of Wnt Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Protein Localization Cytosol Regulation Of Intracellular Signal Transduction P53 Binding Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Microtubule Anchoring At Centrosome Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TOR Signaling Regulation Of Membrane Potential Regulation Of Protein Transport Positive Regulation Of Protein Localization Regulation Of Calcium-mediated Signaling Negative Regulation Of Multicellular Organismal Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Mitotic Cell Cycle	Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nuclear Vitamin D Receptor Binding Developmental Maturation Positive Regulation Of RNA Metabolic Process Labyrinthine Layer Blood Vessel Development
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