ZKSCAN8 and TCEA2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ZKSCAN8	TCEA2
Name		zinc finger with KRAB and SCAN domains 8	transcription elongation factor A2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Centrosome Transcription Elongation Factor Complex Ciliary Basal Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	DNA-templated Transcription DNA-templated Transcription Elongation Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation
Pathways		Generic Transcription Pathway	None
GWAS		Alanine aminotransferase levels ( 33547301 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Fish- and plant-related diet ( 32066663 ) Mean corpuscular volume ( 27863252 ) Refractive error ( 32231278 ) Smoking status (ever vs never smokers) ( 30643258 ) Subcortical volume (MOSTest) ( 32665545 )	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Alanine aminotransferase levels ( 34315874 ) Anxiety ( 31906708 ) Aspartate aminotransferase levels ( 34315874 ) Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Eosinophil count ( 32888494 ) Hip index ( 34021172 ) Low density lipoprotein cholesterol levels ( 32154731 ) Pulse pressure ( 30578418 27841878 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Systolic blood pressure ( 27841878 ) Triglyceride levels ( 29083408 ) Type 2 diabetes (adjusted for BMI) ( 30297969 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		10 interacting genes: APP FBXO7 MAGOH OGT PRNP TCEA2 ZNF165 ZNF174 ZNF24 ZNF587	134 interacting genes: ADAMTSL4 AGR2 AGTRAP AKT1S1 ALAS1 AMOTL2 APP ARMC10 AXIN2 BACH2 BICD2 BOLL BRCA1 BTBD6 CAMKV CBY2 CCDC136 CCDC157 CCSER2 CDK11B CENPT CEP44 CEP70 CEP76 CMTM4 CMTM6 CNTROB COX20 CYSRT1 DAB1 DCAF10 DES DHRS2 DNAJB9 DRC4 DVL3 EAF1 EAF2 ERBB3 EXOSC8 FADD FAM9B FBF1 FCHO1 FXR1 GIGYF1 GOLGA2 GPKOW GPRASP3 GRIPAP1 GTF2B HES7 HIGD1C HIP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 IKZF4 KCNF1 KCTD10 KCTD7 KIAA1958 KRT40 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP5-9 KXD1 LIMS1 LMNA LRRK2 LZTS1 LZTS2 MAGEA11 MARK3 MCC MCM2 MDK MEOX2 MID2 MKRN3 MSANTD4 MTUS2 NAB2 NECAB1 NECAB2 OSBPL3 PIBF1 PICK1 PIH1D2 PNMA1 PNMA5 POU6F2 PRPH RBPMS RETREG3 RPA1 SCYL1 SH3GL2 SSC5D STAC3 STX11 SYNE4 TARBP2 TAX1BP1 TAX1BP3 TBC1D1 TCF4 TEPSIN TFCP2 THAP1 TMEM71 TNIP1 TOX2 TRAF1 TRAF2 TRIM23 TRIM27 TRIM38 TRIM41 TRIM54 TSGA10 USP54 VIM WDR47 ZBTB22 ZBTB43 ZBTB8A ZBTB9 ZKSCAN8 ZNF526
Entrez ID		7745	6919
HPRD ID		03760	16069
Ensembl ID		ENSG00000198315	ENSG00000171703
Uniprot IDs		Q15776 Q59HG5	Q15560 Q6IB64
PDB IDs		Not available	2LW4
GO Terms Enriched among Interactors		Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Cellular Response To Copper Ion Regulation Of Primary Metabolic Process Molecular Function Activator Activity Response To Copper Ion Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Neuron Apoptotic Process DNA Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Amyloid-beta Type 8 Metabotropic Glutamate Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Synapse Organization Regulation Of Carbohydrate Catabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process Autophagy Of Mitochondrion Regulation Of ATP Metabolic Process Nucleus	Identical Protein Binding Protein Binding Intermediate Filament Cytosol