TCEA2 and AKT1S1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TCEA2	AKT1S1
Description		transcription elongation factor A2	AKT1 substrate 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Transcription Elongation Factor Complex Ciliary Basal Body	Nucleoplasm Cytoplasm Cytosol TORC1 Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Kinase Inhibitor Activity Protein Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	DNA-templated Transcription DNA-templated Transcription Elongation Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation	Cytoplasmic Translation Negative Regulation Of Protein Kinase Activity Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Size Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of TORC1 Signaling
Pathways			MTOR signalling mTORC1-mediated signalling AKT phosphorylates targets in the cytosol HSF1-dependent transactivation Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Alanine aminotransferase levels ( 34315874) Anxiety ( 31906708) Aspartate aminotransferase levels ( 34315874) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Eosinophil count ( 32888494) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Pulse pressure ( 30578418 27841878) Serum thyroid-stimulating hormone levels ( 25436638) Systolic blood pressure ( 27841878) Triglyceride levels ( 29083408) Type 2 diabetes (adjusted for BMI) ( 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		134 interacting genes: ADAMTSL4 AGR2 AGTRAP AKT1S1 ALAS1 AMOTL2 APP ARMC10 AXIN2 BACH2 BICD2 BOLL BRCA1 BTBD6 CAMKV CBY2 CCDC136 CCDC157 CCSER2 CDK11B CENPT CEP44 CEP70 CEP76 CMTM4 CMTM6 CNTROB COX20 CYSRT1 DAB1 DCAF10 DES DHRS2 DNAJB9 DRC4 DVL3 EAF1 EAF2 ERBB3 EXOSC8 FADD FAM9B FBF1 FCHO1 FXR1 GIGYF1 GOLGA2 GPKOW GPRASP3 GRIPAP1 GTF2B HES7 HIGD1C HIP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 IKZF4 KCNF1 KCTD10 KCTD7 KIAA1958 KRT40 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP5-9 KXD1 LIMS1 LMNA LRRK2 LZTS1 LZTS2 MAGEA11 MARK3 MCC MCM2 MDK MEOX2 MID2 MKRN3 MSANTD4 MTUS2 NAB2 NECAB1 NECAB2 OSBPL3 PIBF1 PICK1 PIH1D2 PNMA1 PNMA5 POU6F2 PRPH RBPMS RETREG3 RPA1 SCYL1 SH3GL2 SSC5D STAC3 STX11 SYNE4 TARBP2 TAX1BP1 TAX1BP3 TBC1D1 TCF4 TEPSIN TFCP2 THAP1 TMEM71 TNIP1 TOX2 TRAF1 TRAF2 TRIM23 TRIM27 TRIM38 TRIM41 TRIM54 TSGA10 USP54 VIM WDR47 ZBTB22 ZBTB43 ZBTB8A ZBTB9 ZKSCAN8 ZNF526	9 interacting genes: AKT1 AKT2 EIF6 FZR1 MTOR RPS6KA5 TCEA2 YWHAG YWHAQ
Entrez ID		6919	84335
HPRD ID		16069	12441
Ensembl ID		ENSG00000171703	ENSG00000204673
Uniprot IDs		Q15560 Q6IB64	Q96B36
PDB IDs		2LW4	5WBL 5WBU 5WBY 6SB0
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Intermediate Filament Cytosol	Positive Regulation Of Translational Initiation Response To Insulin Positive Regulation Of Translation TORC1 Signaling TOR Signaling Cellular Response To Insulin Stimulus Regulation Of Translational Initiation Response To Peptide Hormone Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Translation Positive Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Translational Initiation Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Translation Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytoplasmic Translational Initiation Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Energy Reserve Metabolic Process Negative Regulation Of Fatty Acid Transport Response To Hormone Post-transcriptional Regulation Of Gene Expression Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Insulin Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Regulation Of Primary Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of TORC1 Signaling Anoikis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Small Molecule Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Response To Hormone Stimulus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC2 Signaling Translation Protein Serine Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transmembrane Transport
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