ZNF24 and DDX6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ZNF24	DDX6
Description		zinc finger protein 24	DEAD-box helicase 6
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Heterochromatin P-body Outer Dense Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Domain Specific Binding Cadherin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Myelination Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Spermatogenesis Negative Regulation Of Translation Viral RNA Genome Packaging Stem Cell Population Maintenance Neuron Differentiation P-body Assembly Stress Granule Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation Spermatid Differentiation
Pathways			mRNA decay by 5' to 3' exoribonuclease
Drugs			D-tartaric acid
Diseases
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 30929738 31619474 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 19838195 28714469) Systemic sclerosis ( 31672989 24387989) Vitiligo ( 22951725)
Interacting Genes		47 interacting genes: APLP1 CEP126 COPS6 CRMP1 DDX6 DZIP3 EEF1A1 EEF1G ERG28 FAM161A FANCA HAP1 HMGB1 KAT5 LMO1 LMO2 LRIF1 MAP1LC3C MID2 NEK6 PPP1CC PRPF31 RBM48 SCAND1 SEC62 SETDB1 TCAF1 TP53 TRIM25 TRIM41 UBE2I UNC119 UTP14A YJU2B ZBTB16 ZGPAT ZKSCAN8 ZNF165 ZNF174 ZNF410 ZNF446 ZNF620 ZNHIT3 ZSCAN12 ZSCAN16 ZSCAN22 ZSCAN32	75 interacting genes: BEGAIN BEND7 BIRC7 CALCOCO2 CCDC136 CCDC14 CEBPA CEP70 CEP76 CNKSR3 CNOT1 DDX17 DES DISC1 DNAAF11 EDC3 EFHC2 ENTR1 FCHO1 GOLGA2 GPRASP3 HOOK2 IK IKZF1 INKA1 JAKMIP1 JUP KLC4 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LZTS1 MAGED1 MESD MTUS2 NAB2 NONO PAK5 PDLIM7 PICK1 PNMA5 POU6F2 PRDM16 PRPH RAPGEF3 RBM11 RBM14 REL RO60 RUNDC3A SCYL1 SHMT1 SLAIN1 SORBS3 SPATA6 SRPK2 STAT1 TCF12 TCF4 TLE5 TP53BP2 TRAF2 TRIM27 TRIM37 TRIM54 U2AF2 USH1G VPS52 ZBTB10 ZBTB14 ZBTB43 ZBTB8A ZC2HC1C ZNF24
Entrez ID		7572	1656
HPRD ID		01921	02638
Ensembl ID		ENSG00000172466	ENSG00000110367
Uniprot IDs		P17028	B2R858 P26196
PDB IDs		1X6E 3LHR	1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding Nucleus Regulation Of Macromolecule Metabolic Process Metal Ion Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Protein Binding Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding	Cytoskeleton Identical Protein Binding Protein Binding Intermediate Filament Cytoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Microtubule Nuclear Speck Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Centriole Replication Transcription Coactivator Activity Intermediate Filament Organization Regulation Of MRNA Processing Regulation Of RNA Metabolic Process Cytosol Negative Regulation Of Centriole Replication Aggresome Tumor Necrosis Factor Receptor Binding Negative Regulation Of Metabolic Process Regulation Of Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of Organelle Organization Regulation Of MRNA Metabolic Process Centrosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament
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