ZNF24 and TRIM25

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZNF24	TRIM25
Description		zinc finger protein 24	tripartite motif containing 25
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Myelination Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Response To Oxidative Stress MRNA Transcription Protein Ubiquitination Viral Release From Host Cell Regulation Of Protein Localization Response To Vitamin D Cellular Response To Oxidative Stress ERAD Pathway RIG-I Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Protein K48-linked Ubiquitination Antiviral Innate Immune Response Cellular Response To Leukemia Inhibitory Factor
Pathways			ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS			Height ( 18391951) Lean body mass ( 28552196)
Interacting Genes		47 interacting genes: APLP1 CEP126 COPS6 CRMP1 DDX6 DZIP3 EEF1A1 EEF1G ERG28 FAM161A FANCA HAP1 HMGB1 KAT5 LMO1 LMO2 LRIF1 MAP1LC3C MID2 NEK6 PPP1CC PRPF31 RBM48 SCAND1 SEC62 SETDB1 TCAF1 TP53 TRIM25 TRIM41 UBE2I UNC119 UTP14A YJU2B ZBTB16 ZGPAT ZKSCAN8 ZNF165 ZNF174 ZNF410 ZNF446 ZNF620 ZNHIT3 ZSCAN12 ZSCAN16 ZSCAN22 ZSCAN32	77 interacting genes: AMFR APC CASP7 CEBPA CHKA CRK DDX3X DICER1 EIF4G3 ERCC2 ERG ESR1 G3BP1 G3BP2 GABARAP GABARAPL1 GABARAPL2 GATA1 GRIK2 LINC00955 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K13 MEIS2 MIR1-1 MIR155 MIR16-2 MIR19B2 MIR205 MIR206 MIR21 MIR221 MIR25 MIR29A MIR29B1 MIR34A MIR363 MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MTA1 OTUB2 PAX2 PIK3R1 PITX2 PLAAT4 PTEN RBCK1 RIPK3 RNF31 SFN SLC26A4-AS1 STK11 STK38 SUMO2 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 YWHAQ ZBTB7A ZNF24
Entrez ID		7572	7706
HPRD ID		01921	02711
Ensembl ID		ENSG00000172466	ENSG00000121060
Uniprot IDs		P17028	Q14258
PDB IDs		1X6E 3LHR	4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding Nucleus Regulation Of Macromolecule Metabolic Process Metal Ion Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Protein Binding Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding	Post-transcriptional Gene Silencing RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nitrogen Starvation MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Phosphatidylethanolamine Binding Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction MRNA 3'-UTR Binding Cellular Response To Stress Negative Regulation Of Gene Expression Post-translational Protein Modification Response To Stress Regulation Of Primary Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Translation Positive Regulation Of Protein Polyubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Regulation Of RNA Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Motility Negative Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Locomotion
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