ZIC2 and GLI1

Number of citations of the paper that reports this interaction (PMID 11238441)
36

Data Source:
HPRD (in vitro)

		ZIC2	GLI1
Gene Name		Zic family member 2	GLI family zinc finger 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Chromatin DNA Binding Metal Ion Binding	DNA Binding Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Microtubule Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Transcription, DNA-templated Brain Development Visual Perception Retinal Ganglion Cell Axon Guidance Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Developmental Pigmentation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Proliferation Regulation Of Smoothened Signaling Pathway Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Notochord Regression Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS		Refractive error ( 23396134)
Protein-Protein Interactions		3 interactors: GLI1 GLI2 GLI3	12 interactors: CDK4 DYRK1A FEM1B GCC1 PRKAA2 RAI1 STK36 SUFU TRIM42 XBP1 ZIC1 ZIC2
Entrez ID		7546	2735
HPRD ID		04353	01311
Ensembl ID		ENSG00000043355	ENSG00000111087
Uniprot IDs		O95409	B4DNF7 F5H6H8 P08151
PDB IDs			2GLI
Enriched GO Terms of Interacting Partners?		Proximal/distal Pattern Formation Notochord Regression Positive Regulation Of Neural Precursor Cell Proliferation Digestive Tract Morphogenesis Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Midline Development Regulation Of Smoothened Signaling Pathway Regulation Of Neural Precursor Cell Proliferation Smoothened Signaling Pathway Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Dorsal/ventral Pattern Formation Digestive Tract Development Digestive System Development Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Hindgut Morphogenesis Notochord Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Hindgut Development Ventral Spinal Cord Interneuron Specification Spinal Cord Motor Neuron Cell Fate Specification Lung Development Anatomical Structure Regression Ventral Spinal Cord Interneuron Fate Commitment Respiratory Tube Development Ventral Spinal Cord Interneuron Differentiation Respiratory System Development Notochord Development Embryonic Organ Morphogenesis Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Spinal Cord Patterning Tube Morphogenesis Dorsal/ventral Neural Tube Patterning Forebrain Development Cerebellar Cortex Morphogenesis Pattern Specification Process Embryonic Digestive Tract Development Embryonic Organ Development Gland Development Spinal Cord Motor Neuron Differentiation Organ Formation Epithelial Cell Differentiation Cerebellum Morphogenesis Hindbrain Morphogenesis Pituitary Gland Development Ventral Spinal Cord Development Neural Tube Patterning	System Development Rhythmic Process Regulation Of Smoothened Signaling Pathway Fatty Acid Homeostasis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Epithelial Cell Maturation Circadian Rhythm Regulation Of Protein Import Into Nucleus Cellular Response To Glucose Starvation Regulation Of Signal Transduction Developmental Process Regulation Of Metabolic Process Regulation Of Protein Localization To Nucleus Organ Development Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Autophagy Regulation Of Signaling Regulation Of RNA Metabolic Process Anion Homeostasis Regulation Of Intracellular Protein Transport Positive Regulation Of Metabolic Process Nervous System Development Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of TOR Signaling Positive Regulation Of Gene Expression Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Epithelial Cell Maturation Involved In Salivary Gland Development Serotonin Secretion, Neurotransmission Response To Insulin-like Growth Factor Stimulus Ammonium Transport Central Nervous System Development Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Cell Differentiation Involved In Salivary Gland Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription, DNA-templated Neural Tube Closure Epithelium Development Negative Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		alobar anteverted bitemporal c1091 consanguineous etiologically fissures frank gli2 gln364leufs holoprosencephaly hpe insipidus insufficiencies mlu mosm nares narrowing neuroanatomic osmolality osmolarity palpebral philtrum prosencephalon sonic syndromic teratogenic trh upslanting	alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss
Tagcloud (Difference) ?		alobar anteverted bitemporal c1091 consanguineous etiologically fissures frank gli2 gln364leufs holoprosencephaly hpe insipidus insufficiencies mlu mosm nares narrowing neuroanatomic osmolality osmolarity palpebral philtrum prosencephalon sonic syndromic teratogenic trh upslanting	alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss
Tagcloud (Intersection) ?