ZIC2

Description		Zic family zinc finger 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Brain Development Visual Perception Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of DNA-binding Transcription Factor Activity
Pathways		Formation of the anterior neural plate
Drugs
Diseases		Holoprosencephaly (HPE)
GWAS		Hyperopia ( 25233373) Myopia ( 27182965) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		3 interacting genes: GLI1 GLI2 GLI3
Entrez ID		7546
HPRD ID		04353
Ensembl ID		ENSG00000043355
Uniprot IDs		O95409
PDB IDs
Enriched GO Terms of Interacting Partners?		GLI-SUFU Complex Proximal/distal Pattern Formation Ciliary Tip Ciliary Base Dorsal/ventral Pattern Formation Ventral Midline Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Hindgut Morphogenesis Lung Development Cerebellar Cortex Morphogenesis Osteoblast Differentiation Double-stranded DNA Binding Spinal Cord Dorsal/ventral Patterning Embryonic Digestive Tract Development Gland Development Regionalization Tube Morphogenesis Pituitary Gland Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Pattern Specification Process Mammary Gland Development Positive Regulation Of DNA Replication Sequence-specific DNA Binding Digestive Tract Development Cilium Odontogenesis Of Dentin-containing Tooth Regulation Of Smoothened Signaling Pathway Epidermal Cell Differentiation Odontogenesis Regulation Of DNA Replication Notochord Regression Axoneme Positive Regulation Of T Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Lateral Semicircular Canal Development Sagittal Suture Morphogenesis Lambdoid Suture Morphogenesis Lateral Ganglionic Eminence Cell Proliferation Anterior Semicircular Canal Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Regulation Of Osteoblast Differentiation Morphogenesis Of A Branching Epithelium DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Morphogenesis Of A Branching Structure Embryonic Organ Development Kidney Development Negative Regulation Of Wnt Signaling Pathway
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