ZIC2 and GLI3

Number of citations of the paper that reports this interaction (PMID 11238441)
36

Data Source:
HPRD (in vivo)

		ZIC2	GLI3
Gene Name		Zic family member 2	GLI family zinc finger 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Mediator Complex Nuclear Speck Transcriptional Repressor Complex Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Chromatin DNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Transcription, DNA-templated Brain Development Visual Perception Retinal Ganglion Cell Axon Guidance Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Developmental Pigmentation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Transcription, DNA-templated Smoothened Signaling Pathway Axon Guidance Hindgut Morphogenesis Heart Development Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Protein Processing Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex Radial Glia Guided Migration Forebrain Radial Glial Cell Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Wound Healing Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Response To Estrogen Negative Thymic T Cell Selection Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Skeletal System Morphogenesis Oligodendrocyte Differentiation Palate Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 is processed to GLI3R by the proteasome
Drugs
Diseases
GWAS		Refractive error ( 23396134)	Age-related macular degeneration ( 23326517) Allergic rhinitis ( 22036096)
Protein-Protein Interactions		3 interactors: GLI1 GLI2 GLI3	17 interactors: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TWIST1 ZIC1 ZIC2 ZIC3
Entrez ID		7546	2737
HPRD ID		04353	01313
Ensembl ID		ENSG00000043355	ENSG00000106571
Uniprot IDs		O95409	P10071
PDB IDs
Enriched GO Terms of Interacting Partners?		Proximal/distal Pattern Formation Notochord Regression Positive Regulation Of Neural Precursor Cell Proliferation Digestive Tract Morphogenesis Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Midline Development Regulation Of Smoothened Signaling Pathway Regulation Of Neural Precursor Cell Proliferation Smoothened Signaling Pathway Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Dorsal/ventral Pattern Formation Digestive Tract Development Digestive System Development Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Hindgut Morphogenesis Notochord Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Hindgut Development Ventral Spinal Cord Interneuron Specification Spinal Cord Motor Neuron Cell Fate Specification Lung Development Anatomical Structure Regression Ventral Spinal Cord Interneuron Fate Commitment Respiratory Tube Development Ventral Spinal Cord Interneuron Differentiation Respiratory System Development Notochord Development Embryonic Organ Morphogenesis Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Spinal Cord Patterning Tube Morphogenesis Dorsal/ventral Neural Tube Patterning Forebrain Development Cerebellar Cortex Morphogenesis Pattern Specification Process Embryonic Digestive Tract Development Embryonic Organ Development Gland Development Spinal Cord Motor Neuron Differentiation Organ Formation Epithelial Cell Differentiation Cerebellum Morphogenesis Hindbrain Morphogenesis Pituitary Gland Development Ventral Spinal Cord Development Neural Tube Patterning	Embryonic Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Tube Morphogenesis Tissue Morphogenesis Positive Regulation Of Transcription, DNA-templated Tube Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Embryo Development Epithelial Tube Morphogenesis Organ Development SMAD Protein Complex Assembly Pattern Specification Process Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Cell Differentiation Epithelium Development Positive Regulation Of Cellular Metabolic Process Heart Development Morphogenesis Of An Epithelium Regulation Of Cell Differentiation Regulation Of Signal Transduction Cardiovascular System Development Tissue Development Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Stem Cell Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter System Development Regulation Of Transcription, DNA-templated Stem Cell Maintenance Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Developmental Process Stem Cell Differentiation Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Transcription From RNA Polymerase II Promoter Response To Growth Factor Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Primary MiRNA Processing
Tagcloud ?		alobar anteverted bitemporal c1091 consanguineous etiologically fissures frank gli2 gln364leufs holoprosencephaly hpe insipidus insufficiencies mlu mosm nares narrowing neuroanatomic osmolality osmolarity palpebral philtrum prosencephalon sonic syndromic teratogenic trh upslanting	act antitumor application blocks cancers combined component could cyclopamine directions downstream enhance glioma gynecological hedgehog induce leading malignancy management mortality oncogene ovarian pathway proliferation reduce signaling silencing therefore
Tagcloud (Difference) ?		alobar anteverted bitemporal c1091 consanguineous etiologically fissures frank gli2 gln364leufs holoprosencephaly hpe insipidus insufficiencies mlu mosm nares narrowing neuroanatomic osmolality osmolarity palpebral philtrum prosencephalon sonic syndromic teratogenic trh upslanting	act antitumor application blocks cancers combined component could cyclopamine directions downstream enhance glioma gynecological hedgehog induce leading malignancy management mortality oncogene ovarian pathway proliferation reduce signaling silencing therefore
Tagcloud (Intersection) ?