ZIC1 and GLI1

Number of citations of the paper that reports this interaction (PubMedID 11238441)
0

Data Source:
HPRD (in vivo, in vitro)

		ZIC1	GLI1
Description		Zic family zinc finger 1	GLI family zinc finger 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Axoneme Ciliary Basal Body Ciliary Tip Ciliary Base GLI-SUFU Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Microtubule Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Nervous System Development Central Nervous System Development Brain Development Adult Walking Behavior Regulation Of Smoothened Signaling Pathway Gene Expression Spinal Cord Development Hippocampus Development Olfactory Bulb Development Cell Differentiation Forebrain Development Positive Regulation Of Protein Import Into Nucleus Inner Ear Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Maintenance Of Cell Number	Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Spermatogenesis Spermatid Development Ventral Midline Development Positive Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Anatomical Structure Morphogenesis Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Cerebellar Cortex Morphogenesis Pituitary Gland Development Cell Differentiation Lung Development Positive Regulation Of Cell Migration Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation
Pathways		Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity	Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Monobrow ( 27182965) Multiple sclerosis ( 19010793) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		71 interacting genes: ABHD11 ANKRD10 ARID5A ATP23 BBS4 CDPF1 CFAP68 CRX CYSRT1 DAPL1 EEF1AKMT3 FAM168B FOXH1 GLI1 GLI2 GLI3 INTS11 KLHL26 KRT31 KRT34 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP22-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LITAF MAGED1 METTL27 MGAT5B NFKBID OIP5 OXER1 PATZ1 PEF1 PLAAT1 PLSCR3 RBPMS REL RFC2 RNF144B RUSC1 SMAD4 SMUG1 SPAG8 SPATS1 SUFU TBX19 TEPSIN TLE5 TRAF1 TRIP6 TSC1 UBE2I UFSP1 WWOX YPEL3 ZNF34 ZNF474 ZNF620	22 interacting genes: AQP1 CATSPER1 CCT2 CRYBA4 DYRK1A FEM1B GCC1 IKBKB PRKAA2 PRKACA PRMT1 PRMT5 RAI1 RUNX3 STK36 SUFU TAF9 TRIM42 WDR77 XBP1 ZIC1 ZIC2
Entrez ID		7545	2735
HPRD ID		02718	01311
Ensembl ID		ENSG00000152977	ENSG00000111087
Uniprot IDs		Q15915	B4DNF7 P08151
PDB IDs			2GLI 4BLB 4KMD 5OM0 7T91
Enriched GO Terms of Interacting Partners?		Intermediate Filament GLI-SUFU Complex Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Cytosol Keratin Filament Spinal Cord Dorsal/ventral Patterning Protein Binding Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Ciliary Base Ciliary Tip Ventral Midline Development Activin Responsive Factor Complex Morphogenesis Of An Epithelium Hindgut Morphogenesis Dorsal/ventral Pattern Formation Cerebellar Cortex Morphogenesis Proximal/distal Pattern Formation Osteoblast Differentiation Tube Morphogenesis Pituitary Gland Development Tissue Morphogenesis Smoothened Signaling Pathway Negative Regulation Of Wnt Signaling Pathway	Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Methylosome Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Smoothened Signaling Pathway Methyl-CpG Binding Protein Serine/threonine/tyrosine Kinase Activity Protein Localization To Lipid Droplet Positive Regulation Of Metabolic Process Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Splicing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Protein Transport Developmental Process Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Nucleoplasm Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Protein Phosphorylation Protein Metabolic Process Protein Serine Kinase Activity Cellular Response To Glucose Stimulus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Import Into Nucleus TORC1 Signaling Regulation Of Gene Expression Regulation Of RNA Splicing Negative Regulation Of TORC1 Signaling Nucleotide-activated Protein Kinase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytoplasm Phosphorylation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Carbohydrate Stimulus Negative Regulation Of Developmental Process Protein Serine/threonine Kinase Activity
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