ZIC1 and PLAAT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZIC1	PLAAT1
Description		Zic family zinc finger 1	phospholipase A and acyltransferase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nuclear Envelope Lumen Cytoplasm Mitochondrion Lysosome Endoplasmic Reticulum Cytosol Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Phospholipase Activity Phospholipase A2 Activity Protein Binding O-acyltransferase Activity Phospholipase A1 Activity N-acyltransferase Activity Transferase Activity Hydrolase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Nervous System Development Central Nervous System Development Brain Development Adult Walking Behavior Regulation Of Smoothened Signaling Pathway Gene Expression Spinal Cord Development Hippocampus Development Olfactory Bulb Development Cell Differentiation Forebrain Development Positive Regulation Of Protein Import Into Nucleus Inner Ear Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Maintenance Of Cell Number	Lipid Metabolic Process Lipid Catabolic Process Phosphatidylcholine Metabolic Process N-acylphosphatidylethanolamine Metabolic Process Lens Fiber Cell Differentiation Organelle Disassembly
Pathways		Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity	Acyl chain remodelling of PE
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Monobrow ( 27182965) Multiple sclerosis ( 19010793) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		71 interacting genes: ABHD11 ANKRD10 ARID5A ATP23 BBS4 CDPF1 CFAP68 CRX CYSRT1 DAPL1 EEF1AKMT3 FAM168B FOXH1 GLI1 GLI2 GLI3 INTS11 KLHL26 KRT31 KRT34 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP22-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LITAF MAGED1 METTL27 MGAT5B NFKBID OIP5 OXER1 PATZ1 PEF1 PLAAT1 PLSCR3 RBPMS REL RFC2 RNF144B RUSC1 SMAD4 SMUG1 SPAG8 SPATS1 SUFU TBX19 TEPSIN TLE5 TRAF1 TRIP6 TSC1 UBE2I UFSP1 WWOX YPEL3 ZNF34 ZNF474 ZNF620	7 interacting genes: APP DNAAF19 GPANK1 HGS TLX3 UBQLN1 ZIC1
Entrez ID		7545	57110
HPRD ID		02718	07577
Ensembl ID		ENSG00000152977	ENSG00000127252
Uniprot IDs		Q15915	Q9HDD0
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament GLI-SUFU Complex Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Cytosol Keratin Filament Spinal Cord Dorsal/ventral Patterning Protein Binding Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Ciliary Base Ciliary Tip Ventral Midline Development Activin Responsive Factor Complex Morphogenesis Of An Epithelium Hindgut Morphogenesis Dorsal/ventral Pattern Formation Cerebellar Cortex Morphogenesis Proximal/distal Pattern Formation Osteoblast Differentiation Tube Morphogenesis Pituitary Gland Development Tissue Morphogenesis Smoothened Signaling Pathway Negative Regulation Of Wnt Signaling Pathway	Central Nervous System Development Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Adult Locomotory Behavior Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Catabolic Process Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Transport Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling ESCRT-0 Complex Phagocytic Vesicle Lumen Macroautophagy Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Neuron Differentiation Regulation Of Toll Signaling Pathway Locomotory Behavior Positive Regulation Of Proteolysis Axon Choice Point Recognition
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