ZIC1 and KRTAP7-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZIC1	KRTAP7-1
Description		Zic family zinc finger 1	keratin associated protein 7-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Intermediate Filament
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Nervous System Development Central Nervous System Development Brain Development Adult Walking Behavior Regulation Of Smoothened Signaling Pathway Gene Expression Spinal Cord Development Hippocampus Development Olfactory Bulb Development Cell Differentiation Forebrain Development Positive Regulation Of Protein Import Into Nucleus Inner Ear Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Maintenance Of Cell Number
Pathways		Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Monobrow ( 27182965) Multiple sclerosis ( 19010793) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		71 interacting genes: ABHD11 ANKRD10 ARID5A ATP23 BBS4 CDPF1 CFAP68 CRX CYSRT1 DAPL1 EEF1AKMT3 FAM168B FOXH1 GLI1 GLI2 GLI3 INTS11 KLHL26 KRT31 KRT34 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP22-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LITAF MAGED1 METTL27 MGAT5B NFKBID OIP5 OXER1 PATZ1 PEF1 PLAAT1 PLSCR3 RBPMS REL RFC2 RNF144B RUSC1 SMAD4 SMUG1 SPAG8 SPATS1 SUFU TBX19 TEPSIN TLE5 TRAF1 TRIP6 TSC1 UBE2I UFSP1 WWOX YPEL3 ZNF34 ZNF474 ZNF620	37 interacting genes: ARID5A C11orf16 C1orf94 CELF5 CREB5 CRYBA2 DTX2 FAM168A FOXH1 GATA2 GCM2 HGS HNRNPF MKRN3 MYOZ3 OTX1 PITX1 PITX2 PRR13 PSMB1 RANBP3 RHOXF2 RNF38 ROR2 SHARPIN SMARCC1 SNRPC SPAG8 TCF7L2 TEKT4 TFAP2D TLE5 TLX3 TOLLIP VPS37C YTHDF1 ZIC1
Entrez ID		7545	337878
HPRD ID		02718	19546
Ensembl ID		ENSG00000152977	ENSG00000274749
Uniprot IDs		Q15915	Q8IUC3
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament GLI-SUFU Complex Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Cytosol Keratin Filament Spinal Cord Dorsal/ventral Patterning Protein Binding Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Ciliary Base Ciliary Tip Ventral Midline Development Activin Responsive Factor Complex Morphogenesis Of An Epithelium Hindgut Morphogenesis Dorsal/ventral Pattern Formation Cerebellar Cortex Morphogenesis Proximal/distal Pattern Formation Osteoblast Differentiation Tube Morphogenesis Pituitary Gland Development Tissue Morphogenesis Smoothened Signaling Pathway Negative Regulation Of Wnt Signaling Pathway	DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Chromatin Myoblast Fate Commitment Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Pituitary Gland Development Nucleus Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Gland Development GABAergic Neuron Differentiation DNA Binding Inner Ear Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Axonemal A Tubule Inner Sheath Nuclear Androgen Receptor Binding Ubiquitin Binding Protein Binding R-SMAD Binding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Embryonic Hindlimb Morphogenesis Regulation Of Metabolic Process Diencephalon Morphogenesis Superior Vena Cava Morphogenesis Subthalamic Nucleus Development Multivesicular Body Assembly MRNA Splice Site Recognition Multivesicular Body Organization
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