GFAP and ZNF774

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GFAP	ZNF774
Description		glial fibrillary acidic protein	zinc finger protein 774
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Cytoskeleton Intermediate Filament Membrane Cell Projection Cell Body Intermediate Filament Cytoskeleton Glial Cell Projection Astrocyte Projection Astrocyte End-foot Cytoplasmic Side Of Lysosomal Membrane	Nucleus
	Molecular Function	Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Kinase Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Gene Expression Positive Regulation Of Schwann Cell Proliferation Negative Regulation Of Neuron Projection Development Astrocyte Development Schwann Cell Proliferation Extracellular Matrix Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Protein-containing Complex Assembly Intermediate Filament-based Process Intermediate Filament Organization Regulation Of Neurotransmitter Uptake Bergmann Glial Cell Differentiation Positive Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation D-aspartate Import Across Plasma Membrane Regulation Of Chaperone-mediated Autophagy	Regulation Of Transcription By RNA Polymerase II
Pathways		Nuclear signaling by ERBB4 Chaperone Mediated Autophagy	Generic Transcription Pathway
Drugs
Diseases		Alexander disease
GWAS		Asthma ( 31619474) Cognitive function ( 25644384) Craniofacial microsomia ( 26853712)	Male-pattern baldness ( 28196072) Rheumatoid arthritis ( 22446963)
Interacting Genes		86 interacting genes: ABI2 AKT1 APP AURKB BIRC2 CAMK2A CARD10 CCDC57 CDC37 CDK1 CEP76 CFAP206 CRYAB CT55 CWF19L2 DSCAM ENKD1 EPM2AIP1 FAM50B FXR1 FXR2 GOLGA2 GRAP2 HGS HOMEZ IKBKG ITSN1 KIAA0408 KRT13 KRT15 KRT19 KRT27 KRT31 KRT39 LENG1 LGALS14 LMO2 MAPK9 MEN1 MOS MYBPHL MYO15B NEFL NEIL3 NEK6 NFKBID NTAQ1 NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PPP1R16B PPP1R18 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SMARCA2 SMARCB1 SRC STAT1 TBC1D21 TBC1D22B TFIP11 TLE5 TP53BP2 TRIM27 TSC1 TUBGCP4 UBASH3A UBE3A VIM YES1 ZC2HC1C ZNF655 ZNF774	77 interacting genes: BACH2 BEGAIN BLK BOLA2 BOLA2B CABP2 CALCOCO2 CARD9 CATSPER1 CCDC102B CCDC136 CCDC6 CCHCR1 CDK18 CDKN2D CEP63 CIB3 COL8A1 CPNE7 DTX2 DVL3 EFEMP2 EMD FAM124B FSD2 GABARAPL2 GEM GFAP GLRX3 GOLGA1 GOLGA2 GTPBP3 GYS1 GZMM HOXA1 HOXB5 HSF2BP IL16 IPO8 KANK2 KIFC3 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP4-5 LDOC1 LONRF1 MAGOHB MID2 MLH1 MTUS2 MYO15B NDOR1 NEK6 NID2 PIBF1 PICK1 PRPF31 PSMB1 RABEP1 RAD51D RBM11 SCNM1 SH2D4A SMAD3 STK16 TRAF2 TSTD2 USP49 VWC2 YJU2B ZNF165 ZNF417 ZNF48 ZNF526 ZNF572 ZNF587
Entrez ID		2670	342132
HPRD ID		00675	17571
Ensembl ID		ENSG00000131095	ENSG00000196391
Uniprot IDs		A0A1X7SBR3 P14136	Q6NX45
PDB IDs		6A9P
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Intermediate Filament Organization Cytoskeleton Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Protein Serine/threonine/tyrosine Kinase Activity Intracellular Signal Transduction Structural Constituent Of Skin Epidermis Cytoplasm Protein Kinase Activity Intermediate Filament Protein Serine Kinase Activity Regulation Of Cellular Component Organization Microtubule Cytoskeleton Organization Organelle Organization Response To Peptide Hormone Positive Regulation Of Signaling Regulation Of Generation Of Precursor Metabolites And Energy Protein Serine/threonine Kinase Activity Protein-containing Complex Keratin Filament Regulation Of Synaptic Plasticity Protein Phosphorylation Nucleus Kinase Activity Regulation Of Neuronal Synaptic Plasticity Structural Constituent Of Cytoskeleton Response To Hormone Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Cytosol Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Regulation Of Apoptotic Process Synaptic Membrane Mitotic Nuclear Membrane Disassembly Developmental Process Negative Regulation Of TORC1 Signaling Intracellular Signaling Cassette Regulation Of Proteolysis Phosphorylation Regulation Of Circadian Rhythm Regulation Of Signaling Positive Regulation Of Gene Expression Regulation Of Cell Communication Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Structural Molecule Activity	Protein Binding Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly Complex
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