MSX2 and CEBPA

Number of citations of the paper that reports this interaction (PMID 12925529)
76

Data Source:
HPRD (in vitro, in vivo)

		MSX2	CEBPA
Gene Name		msh homeobox 2	CCAAT/enhancer binding protein (C/EBP), alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Nuclear Matrix Rb-E2F Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Cofactor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Complex Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Chondrocyte Development Osteoblast Development Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endochondral Bone Growth Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of BMP Signaling Pathway Negative Regulation Of CREB Transcription Factor Activity Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Embryonic Nail Plate Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Catagen Bone Trabecula Formation Cranial Suture Morphogenesis Frontal Suture Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis BMP Signaling Pathway Involved In Heart Development Enamel Mineralization Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Activation Of Meiosis Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process	Urea Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Embryonic Placenta Development Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Acute-phase Response Mitochondrion Organization Cholesterol Metabolic Process Negative Regulation Of Cell Proliferation Viral Process Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Macrophage Differentiation Lung Development Organ Regeneration Response To Vitamin B2 Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Cell Maturation Inner Ear Development White Fat Cell Differentiation Brown Fat Cell Differentiation Response To Glucocorticoid Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound
Pathways			Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ATXN1 CEBPA DLX2 DLX5 GTF2F1 GTF2F2 MAGED1 MSX1 NR3C1 PIAS2 POLR3D POU2AF1 PPARG RUNX2 SPEN TLE1 TLE2 XRCC5 XRCC6 ZBTB17 ZDHHC2	56 interactors: AR ATF2 ATF3 ATF4 ATF5 BATF BATF2 BATF3 C1QBP CDK2 CDK4 CDKN1A CDKN3 CDX1 CEBPB CEBPD CEBPE CEBPG CREBBP CTNNB1 DBP EDF1 EP300 ESR1 FOS FOSL1 GATA2 GSK3B HNF1A MAPK8 MSX2 MYC NCOA6 NFYA NR3C1 PIAS1 RARA RARB RASGRF1 RB1 RBL1 RFC1 RUNX1 SKP2 SMAD3 SMAD4 SMARCA2 SMARCA4 SOX10 SOX8 SPI1 SRA1 SUMO3 XRCC5 XRCC6 ZBTB16
Entrez ID		4488	1050
HPRD ID		00421	00296
Ensembl ID		ENSG00000120149	ENSG00000245848
Uniprot IDs		P35548	P49715
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Cellular Hyperosmotic Salinity Response DNA-templated Transcription, Initiation Organ Development Response To Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Signaling Multicellular Organismal Development Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Differentiation Viral Process Regulation Of Signal Transduction Anatomical Structure Development System Development	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated System Development Multicellular Organismal Development Cellular Metabolic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Cell Differentiation Regulation Of Cell Proliferation Regulation Of Cell Differentiation Tissue Development Myeloid Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Death Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		achondroplasia attendant clefts collins craniosynostosis crest crouzon deformities dentofacial detoxifying excessively ganglionic hemifacial holoprosencephaly jaws kills malocclusions merging microsomia mismatches neuromeres ordinated palatal placodal placodes prominences radically shelves treacher	acting additive c38 c40 caat cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent pou pou3f1 redundant repress robust
Tagcloud (Difference) ?		achondroplasia attendant clefts collins craniosynostosis crest crouzon deformities dentofacial detoxifying excessively ganglionic hemifacial holoprosencephaly jaws kills malocclusions merging microsomia mismatches neuromeres ordinated palatal placodal placodes prominences radically shelves treacher	acting additive c38 c40 caat cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent pou pou3f1 redundant repress robust
Tagcloud (Intersection) ?