MSX2 and XRCC6

Number of citations of the paper that reports this interaction (PubMedID 12145306)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MSX2	XRCC6
Description		msh homeobox 2	X-ray repair cross complementing 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytosol Nuclear Speck	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Catalytic Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity Lyase Activity ATP Hydrolysis Activity Cyclin Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation Chondrocyte Development Osteoblast Development Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endochondral Bone Growth Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Signal Transduction Involved In Regulation Of Gene Expression Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Embryonic Nail Plate Morphogenesis Wound Healing Odontogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Embryonic Morphogenesis Stem Cell Differentiation Cartilage Development Positive Regulation Of Timing Of Catagen Bone Trabecula Formation Bone Morphogenesis Cranial Suture Morphogenesis Frontal Suture Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Epithelium Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Enamel Mineralization Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Activation Of Meiosis Mesenchymal Cell Apoptotic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process	Telomere Maintenance Recombinational Repair Activation Of Innate Immune Response Immune System Process Positive Regulation Of Immune System Process DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To Ionizing Radiation Negative Regulation Of Macromolecule Biosynthetic Process Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		Regulation of RUNX2 expression and activity	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs
Diseases		Enlarged parietal foramina/cranium bifidum Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alzheimer's disease ( 33074286) Blond vs. brown/black hair color ( 30531825) Chin dimples ( 27182965) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Red vs. brown/black hair color ( 30531825) Resistant hypertension ( 30237584) Stroke ( 26089329)	Asthma ( 34103634) Breast cancer ( 29059683) Meat-related diet ( 32066663) Neuroticism ( 29255261) Pulse pressure ( 28135244) Refractive error ( 32231278)
Interacting Genes		53 interacting genes: ATXN1 CCDC102B CEBPA CLIC3 DLX2 DLX5 EPHB6 FBXW2 FOXH1 GATA2 GTF2F1 GTF2F2 HOXC9 LENG8 MAGED1 MAPK1 MAPK1IP1L MGAT5B MSX1 NAF1 NR3C1 PATZ1 PIAS2 PITX1 POLR3D POU1F1 POU2AF1 POU2F2 POU6F2 PPARG PRR13 RBPMS2 RHOXF2 RUNX2 SMAP2 SOX5 SPEN TCF7L2 TENT5D TLE1 TLE2 TLE5 TLX3 TOLLIP TSSK3 VEZF1 XRCC5 XRCC6 YTHDF1 ZBTB17 ZC3H10 ZDHHC2 ZFHX3	144 interacting genes: ABCD4 ABL1 ACD ADCY7 ANXA1 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCNB1 CCT3 CD40 CDCA5 CDK1 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DEAF1 DLX2 DNTT DSCR4 DUX4 DYRK1A DYSF EFNA1 EGFR EID1 EIF4ENIF1 ELF3 EP300 EPS8 ETS1 FCER2 FILNC1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HACL2 HERPUD1 HOXB7 HOXC4 HOXD4 HSF1 HTT JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 OGT PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTEN PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF10 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERT TP53 UBC USP14 VAV1 VBP1 WBP4 WEE2-AS1 WRN XRCC5 YWHAZ ZBTB7A ZNF512B
Entrez ID		4488	2547
HPRD ID		00421	01071
Ensembl ID		ENSG00000120149	ENSG00000196419
Uniprot IDs		D6RIS4 P35548	B1AHC9 B4DE32 B4E356 P12956
PDB IDs			1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH 6ZHA 6ZHE 7AXZ 7K0Y 7K1J 7K1K 7K1N 7LSY 7LT3 7NFC 7NFE 7SGL 7SU3 7Z6O 7Z87 7Z88 7ZT6 7ZVT 7ZWA 7ZYG 8AG4 8AG5 8ASC 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB 8RD4
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis DNA-templated Transcription Sequence-specific Double-stranded DNA Binding Nucleoplasm Cell Fate Commitment Positive Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation GABAergic Neuron Differentiation Developmental Process Transcription Factor TFIIF Complex Protein-DNA Complex	Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Response To Stress DNA Metabolic Process DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Protein-containing Complex Regulation Of Protein Stability Chromatin Negative Regulation Of Programmed Cell Death Double-strand Break Repair Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Repair Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II
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