MSX2 and GTF2F2

Number of citations of the paper that reports this interaction (PMID 9265625)
10

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MSX2	GTF2F2
Gene Name		msh homeobox 2	general transcription factor IIF, polypeptide 2, 30kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Nucleoplasm Transcription Factor TFIIF Complex Microtubule Cytoskeleton
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Cofactor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	DNA Binding Protein Binding ATP Binding ATP-dependent Helicase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Chondrocyte Development Osteoblast Development Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endochondral Bone Growth Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of BMP Signaling Pathway Negative Regulation Of CREB Transcription Factor Activity Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Embryonic Nail Plate Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Catagen Bone Trabecula Formation Cranial Suture Morphogenesis Frontal Suture Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis BMP Signaling Pathway Involved In Heart Development Enamel Mineralization Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Activation Of Meiosis Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process Positive Regulation Of Viral Transcription
Pathways			RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Influenza Life Cycle HIV elongation arrest and recovery HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Influenza Viral RNA Transcription and Replication RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Viral Messenger RNA Synthesis RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ATXN1 CEBPA DLX2 DLX5 GTF2F1 GTF2F2 MAGED1 MSX1 NR3C1 PIAS2 POLR3D POU2AF1 PPARG RUNX2 SPEN TLE1 TLE2 XRCC5 XRCC6 ZBTB17 ZDHHC2	25 interactors: AHR AR ARNT ATF2 ATF4 CEBPG CREB1 FOS GTF2B GTF2E1 GTF2E2 GTF2F1 HMGA1 HTATSF1 JUN KLF5 MSX2 POLR2E RPL27A TAF5 TBP TCEA1 TCTEX1D2 TRAM2 URI1
Entrez ID		4488	2963
HPRD ID		00421	01804
Ensembl ID		ENSG00000120149	ENSG00000188342
Uniprot IDs		P35548	P13984
PDB IDs			1BBY 1F3U 2BBY
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Cellular Hyperosmotic Salinity Response DNA-templated Transcription, Initiation Organ Development Response To Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Signaling Multicellular Organismal Development Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Differentiation Viral Process Regulation Of Signal Transduction Anatomical Structure Development System Development	Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Viral Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Transcription MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Viral Process Positive Regulation Of Myeloid Cell Differentiation Toll-like Receptor 4 Signaling Pathway
Tagcloud ?		achondroplasia attendant clefts collins craniosynostosis crest crouzon deformities dentofacial detoxifying excessively ganglionic hemifacial holoprosencephaly jaws kills malocclusions merging microsomia mismatches neuromeres ordinated palatal placodal placodes prominences radically shelves treacher	antitumoral around cancerous chose delta exert fresh house involve isoform isoforms lactoferrin lactoferrins mb mda mfpaq principal proteome proteomic proven quantified re secretory selh silac software stably suppressors ube2e1
Tagcloud (Difference) ?		achondroplasia attendant clefts collins craniosynostosis crest crouzon deformities dentofacial detoxifying excessively ganglionic hemifacial holoprosencephaly jaws kills malocclusions merging microsomia mismatches neuromeres ordinated palatal placodal placodes prominences radically shelves treacher	antitumoral around cancerous chose delta exert fresh house involve isoform isoforms lactoferrin lactoferrins mb mda mfpaq principal proteome proteomic proven quantified re secretory selh silac software stably suppressors ube2e1
Tagcloud (Intersection) ?