MSX2 and ZDHHC2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		MSX2	ZDHHC2
Description		msh homeobox 2	zDHHC palmitoyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytosol Nuclear Speck	Golgi Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Synapse Recycling Endosome Membrane Postsynaptic Recycling Endosome Postsynaptic Recycling Endosome Membrane Glutamatergic Synapse
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Protein Homodimerization Activity Protein-cysteine S-stearoyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation Chondrocyte Development Osteoblast Development Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endochondral Bone Growth Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Signal Transduction Involved In Regulation Of Gene Expression Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Embryonic Nail Plate Morphogenesis Wound Healing Odontogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Embryonic Morphogenesis Stem Cell Differentiation Cartilage Development Positive Regulation Of Timing Of Catagen Bone Trabecula Formation Bone Morphogenesis Cranial Suture Morphogenesis Frontal Suture Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Epithelium Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Enamel Mineralization Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Activation Of Meiosis Mesenchymal Cell Apoptotic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process	Protein Targeting To Membrane Synapse Assembly Synaptic Vesicle Maturation Peptidyl-L-cysteine S-palmitoylation Regulation Of Cell-cell Adhesion Regulation Of Protein Catabolic Process Regulation Of Neuronal Synaptic Plasticity Protein Localization To Plasma Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Positive Regulation Of Long-term Synaptic Potentiation Protein Localization To Membrane Raft Regulation Of Protein Localization To Plasma Membrane Protein Localization To Postsynaptic Membrane Positive Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of Endosome To Plasma Membrane Protein Transport
Pathways		Regulation of RUNX2 expression and activity	Surfactant metabolism Maturation of spike protein
Drugs
Diseases		Enlarged parietal foramina/cranium bifidum Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alzheimer's disease ( 33074286) Blond vs. brown/black hair color ( 30531825) Chin dimples ( 27182965) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Red vs. brown/black hair color ( 30531825) Resistant hypertension ( 30237584) Stroke ( 26089329)	Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Parkinson's disease ( 32201043) Schizophrenia ( 28991256 30285260) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		53 interacting genes: ATXN1 CCDC102B CEBPA CLIC3 DLX2 DLX5 EPHB6 FBXW2 FOXH1 GATA2 GTF2F1 GTF2F2 HOXC9 LENG8 MAGED1 MAPK1 MAPK1IP1L MGAT5B MSX1 NAF1 NR3C1 PATZ1 PIAS2 PITX1 POLR3D POU1F1 POU2AF1 POU2F2 POU6F2 PPARG PRR13 RBPMS2 RHOXF2 RUNX2 SMAP2 SOX5 SPEN TCF7L2 TENT5D TLE1 TLE2 TLE5 TLX3 TOLLIP TSSK3 VEZF1 XRCC5 XRCC6 YTHDF1 ZBTB17 ZC3H10 ZDHHC2 ZFHX3	2 interacting genes: MAFB MSX2
Entrez ID		4488	51201
HPRD ID		00421	15715
Ensembl ID		ENSG00000120149	ENSG00000104219
Uniprot IDs		D6RIS4 P35548	A0A140VKD9 Q9UIJ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis DNA-templated Transcription Sequence-specific Double-stranded DNA Binding Nucleoplasm Cell Fate Commitment Positive Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation GABAergic Neuron Differentiation Developmental Process Transcription Factor TFIIF Complex Protein-DNA Complex	Transcription Regulator Complex Pattern Specification Process Positive Regulation Of Timing Of Catagen Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Embryonic Morphogenesis Regulation Of Timing Of Catagen Activation Of Meiosis Positive Regulation Of Mesenchymal Cell Apoptotic Process Frontal Suture Morphogenesis Regionalization Brain Segmentation Abducens Nerve Formation Rhombomere 5 Development Rhombomere 6 Development Sequence-specific DNA Binding Cornified Envelope Assembly Cranial Suture Morphogenesis Sequence-specific Double-stranded DNA Binding Enamel Mineralization Endochondral Bone Growth Negative Regulation Of Keratinocyte Differentiation Bone Trabecula Formation Negative Regulation Of Erythrocyte Differentiation Rhombomere Development Mammary Gland Epithelium Development Positive Regulation Of Hair Follicle Development Mesenchymal Cell Apoptotic Process Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Cell Differentiation Negative Regulation Of Epidermal Cell Differentiation Cardiac Conduction System Development Positive Regulation Of Meiotic Nuclear Division Wound Healing, Spreading Of Epidermal Cells Osteoblast Development Segment Specification Craniofacial Suture Morphogenesis Bone Growth Tooth Mineralization Branching Involved In Mammary Gland Duct Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Hair Follicle Development Chondrocyte Development Positive Regulation Of Meiotic Cell Cycle Negative Regulation Of Developmental Process Outflow Tract Septum Morphogenesis Regulation Of Hair Cycle Negative Regulation Of Transcription By RNA Polymerase II Embryonic Hindlimb Morphogenesis Cardiac Epithelial To Mesenchymal Transition
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