PDX1 and ATF3

Number of citations of the paper that reports this interaction (PMID 21986529)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PDX1	ATF3
Gene Name		pancreatic and duodenal homeobox 1	activating transcription factor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Complex Binding Protein Heterodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Nitric Oxide Mediated Signal Transduction Central Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Wounding Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Organ Senescence Positive Regulation Of Cell Death Morphogenesis Of Embryonic Epithelium Insulin Secretion Exocrine Pancreas Development Endocrine Pancreas Development Organ Regeneration Positive Regulation Of Insulin Secretion Response To Vitamin Response To Cytokine Response To Nicotine Response To Drug Glucose Homeostasis Response To Leucine Positive Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Stem Cell Differentiation Response To Glucocorticoid Detection Of Glucose Transdifferentiation Response To Fatty Acid Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gluconeogenesis Transcription, DNA-templated Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Cell Proliferation Endoplasmic Reticulum Unfolded Protein Response Skeletal Muscle Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Regulation of beta-cell development Regulation of gene expression in early pancreatic precursor cells Regulation of gene expression in beta cells	ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Fasting glucose-related traits (interaction with BMI) ( 22581228)
Protein-Protein Interactions		13 interactors: ATF3 CREB1 IAPP MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6	41 interactors: ATF2 ATF4 BATF BATF3 CEBPA CEBPE CEBPG CREB3 CREBBP DBP DDIT3 FGFR3 FOS FOSL1 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 ID3 IGSF21 JUN JUNB JUND LRIF1 MAFF MAFG MDM2 NFKB1 NUF2 PDX1 POLR3D SMAD3 SRA1 SS18L1 STAT1 SUMO1 SUMO3 SUV39H1 TP53 ZNF212
Entrez ID		3651	467
HPRD ID		02843	04395
Ensembl ID		ENSG00000139515	ENSG00000162772
Uniprot IDs		P52945	P18847
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Double-strand Break Repair Via Nonhomologous End Joining Organ Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Hyperosmotic Salinity Response Positive Regulation Of Gene Expression V(D)J Recombination Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Brain Development Head Development Cellular Response To X-ray Endocrine Pancreas Development Immunoglobulin V(D)J Recombination System Development DNA Recombination Central Nervous System Development Transcription, DNA-templated Regulation Of Cell Differentiation Establishment Of Integrated Proviral Latency Anterior/posterior Pattern Specification RNA Biosynthetic Process Cellular Hyperosmotic Response Hyperosmotic Salinity Response Telomere Maintenance Positive Regulation Of Type I Interferon Production B Cell Lineage Commitment Establishment Of Viral Latency Positive Regulation Of Cellular Metabolic Process Cellular Response To Salt Stress Multicellular Organismal Development Pancreas Development Anatomical Structure Development Immune System Development Regulation Of Neurogenesis Regulation Of Type I Interferon Production Nitric Oxide Mediated Signal Transduction Negative Regulation Of Cellular Metabolic Process Innate Immune Response Regulation Of Protein Stability Immune System Process Positive Regulation Of Neurogenesis Regulation Of Cell Development Positive Regulation Of Cell Differentiation Response To Ionizing Radiation Developmental Process Double-strand Break Repair Transcription From RNA Polymerase II Promoter Hyperosmotic Response	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Cellular Metabolic Process Response To Organic Substance Regulation Of Cell Differentiation Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Defense Response Cellular Response To Organic Substance Cell Differentiation Immune System Process Histone H3-K9 Modification Developmental Process Rhythmic Process Regulation Of Cell Death Response To Biotic Stimulus
Tagcloud ?		ablate ablated adenoviral carry cycles ductal ganciclovir gcv implants intraperitoneal ip iv liposomal longest microg minimal monitored panc pancreatic pdac repeated scid superior suppresses survived thymidine tk toxicity vectors	activating attenuation beneficial caat chop combating contributes diabetogenic dietary elevation elicited endoplasmic enhancer evoked fatty hdac1 hdac3 homologous islets lipotoxicity mimicked min6 ms palmitate preserving prevents reticulum saturated silencing
Tagcloud (Difference) ?		ablate ablated adenoviral carry cycles ductal ganciclovir gcv implants intraperitoneal ip iv liposomal longest microg minimal monitored panc pancreatic pdac repeated scid superior suppresses survived thymidine tk toxicity vectors	activating attenuation beneficial caat chop combating contributes diabetogenic dietary elevation elicited endoplasmic enhancer evoked fatty hdac1 hdac3 homologous islets lipotoxicity mimicked min6 ms palmitate preserving prevents reticulum saturated silencing
Tagcloud (Intersection) ?