PDX1 and SLC2A2

Number of citations of the paper that reports this interaction (PMID 8923459)
59

Data Source:
HPRD (in vivo)

		PDX1	SLC2A2
Gene Name		pancreatic and duodenal homeobox 1	solute carrier family 2 (facilitated glucose transporter), member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Complex Binding Protein Heterodimerization Activity	Glucose Transmembrane Transporter Activity Hexose Transmembrane Transporter Activity Dehydroascorbic Acid Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Nitric Oxide Mediated Signal Transduction Central Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Wounding Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Organ Senescence Positive Regulation Of Cell Death Morphogenesis Of Embryonic Epithelium Insulin Secretion Exocrine Pancreas Development Endocrine Pancreas Development Organ Regeneration Positive Regulation Of Insulin Secretion Response To Vitamin Response To Cytokine Response To Nicotine Response To Drug Glucose Homeostasis Response To Leucine Positive Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Stem Cell Differentiation Response To Glucocorticoid Detection Of Glucose Transdifferentiation Response To Fatty Acid Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Carbohydrate Metabolic Process Energy Reserve Metabolic Process Hexose Transport Pathogenesis Glucose Transport Endocrine Pancreas Development Hexose Transmembrane Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Dehydroascorbic Acid Transport
Pathways		Regulation of beta-cell development Regulation of gene expression in early pancreatic precursor cells Regulation of gene expression in beta cells	Integration of energy metabolism Regulation of insulin secretion Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport Hexose transport Regulation of beta-cell development Myoclonic epilepsy of Lafora Facilitative Na+-independent glucose transporters Glycogen storage diseases Regulation of gene expression in beta cells Glucose transport Metabolism of carbohydrates
Drugs			Streptozocin
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Fasting glucose-related traits (interaction with BMI) ( 22581228)	Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		13 interactors: ATF3 CREB1 IAPP MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6	4 interactors: APP KPNA2 PDX1 PRKACA
Entrez ID		3651	6514
HPRD ID		02843	00685
Ensembl ID		ENSG00000139515	ENSG00000163581
Uniprot IDs		P52945	B7Z547 F8W8V8 P11168 Q6PAU8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Double-strand Break Repair Via Nonhomologous End Joining Organ Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Hyperosmotic Salinity Response Positive Regulation Of Gene Expression V(D)J Recombination Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Brain Development Head Development Cellular Response To X-ray Endocrine Pancreas Development Immunoglobulin V(D)J Recombination System Development DNA Recombination Central Nervous System Development Transcription, DNA-templated Regulation Of Cell Differentiation Establishment Of Integrated Proviral Latency Anterior/posterior Pattern Specification RNA Biosynthetic Process Cellular Hyperosmotic Response Hyperosmotic Salinity Response Telomere Maintenance Positive Regulation Of Type I Interferon Production B Cell Lineage Commitment Establishment Of Viral Latency Positive Regulation Of Cellular Metabolic Process Cellular Response To Salt Stress Multicellular Organismal Development Pancreas Development Anatomical Structure Development Immune System Development Regulation Of Neurogenesis Regulation Of Type I Interferon Production Nitric Oxide Mediated Signal Transduction Negative Regulation Of Cellular Metabolic Process Innate Immune Response Regulation Of Protein Stability Immune System Process Positive Regulation Of Neurogenesis Regulation Of Cell Development Positive Regulation Of Cell Differentiation Response To Ionizing Radiation Developmental Process Double-strand Break Repair Transcription From RNA Polymerase II Promoter Hyperosmotic Response	Regulation Of Binding Regulation Of Cellular Ketone Metabolic Process Response To Wounding Response To Cytokine Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Dense Core Granule Biogenesis Response To Glucose Chemical Homeostasis Second-messenger-mediated Signaling Glucose Metabolic Process Regulation Of Protein Binding Cell Maturation Morphogenesis Of Embryonic Epithelium Cell Surface Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Organ Senescence Histone H3-T6 Phosphorylation Response To Carbohydrate Platelet Activation Regulation Of Insulin Secretion Glucose Homeostasis Hexose Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Collateral Sprouting In Absence Of Injury Detection Of Glucose Regulation Of Peptide Hormone Secretion Positive Regulation Of Cell Cycle Process Response To Chlorate Monosaccharide Metabolic Process Regulation Of Hormone Secretion Homeostatic Process Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Iron(II) Ion Regulation Of Phosphorus Metabolic Process Calcium Ion Homeostasis Response To Leucine Peptidyl-serine Autophosphorylation Axon Choice Point Recognition Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Protein Transport Positive Regulation Of Cellular Biosynthetic Process Response To Light Stimulus Extracellular Matrix Organization
Tagcloud ?		ablate ablated adenoviral carry cycles ductal ganciclovir gcv implants intraperitoneal ip iv liposomal longest microg minimal monitored panc pancreatic pdac repeated scid superior suppresses survived thymidine tk toxicity vectors	aav abcc8 adeno administrations cxcl12 cxcl13 damaged fkbp1b foxa2 g6pc2 gad1 glp glucosamine glut2 isl1 islets neurod1 nitrosourea nkx6 nptx2 pdx1 preserve prss53 sdf slc30a8 stz tmem229b ttc28 ucn3
Tagcloud (Difference) ?		ablate ablated adenoviral carry cycles ductal ganciclovir gcv implants intraperitoneal ip iv liposomal longest microg minimal monitored panc pancreatic pdac repeated scid superior suppresses survived thymidine tk toxicity vectors	aav abcc8 adeno administrations cxcl12 cxcl13 damaged fkbp1b foxa2 g6pc2 gad1 glp glucosamine glut2 isl1 islets neurod1 nitrosourea nkx6 nptx2 preserve prss53 sdf slc30a8 stz tmem229b ttc28 ucn3
Tagcloud (Intersection) ?		pdx1